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Merck
CN

SAB5701890

Sigma-Aldrich

Anti-Phospho-SHC1-Y317 antibody produced in rabbit

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About This Item

UNSPSC代码:
12352203
NACRES:
NA.41
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生物来源

rabbit

质量水平

抗体产品类型

primary antibodies

克隆

polyclonal

表单

liquid

种属反应性

human

浓度

2.34 mg/mL

技术

western blot: 1:500-1:2000

UniProt登记号

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

phosphorylation (pTyr317)

基因信息

human ... SHC1(6464)

一般描述

This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

免疫原

A phospho specific peptide corresponding to residues surrounding Y317 of human SHC1.

外形

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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