Anti-Chk1 Antibody, clone 0S3Q1, Rabbit Monoclonal

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Chk1 (O14757).

WB, IHC

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]