KD-Validated Anti PTTG1 Antibody, clone 24GB1495, Rabbit Monoclonal

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]

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A synthesized peptide corresponding to a sequence within amino acids 100-149 of human Securin [NP_001269311.1].

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.

Solution in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.