SAB6012507
KD-Validated Anti MLKL Antibody, clone 23GB2895, Rabbit Monoclonal
clone 23GB2895, recombinant rabbit monoclonal, expressed in HEK293 cells
别名:
FLJ34389, HMLKL
产品名称
KD-Validated Anti MLKL Antibody, clone 23GB2895, Rabbit Monoclonal, clone 23GB2895, recombinant rabbit monoclonal, expressed in HEK293 cells
biological source
rabbit (Monoclonal)
recombinant
expressed in HEK 293 cells
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
23GB2895, recombinant monoclonal
form
buffered aqueous glycerol solution
mol wt
54 kDa
species reactivity
human
packaging
vial of 1.5 mL
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
Quality Level
Gene Information
human ... MLKL(197259)
sustainability
Greener Alternative Product
concentration
1.5 mg/ml
technique(s)
flow cytometry: 1:2000
immunofluorescence: 1:100-:1000
western blot: 1:1,000-1:5,000
isotype
IgG
Ensembl | human accession no.
NCBI accession no.
UniProt accession no.
greener alternative category
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
General description
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
We are committed to bringing you Greener Alternative Products. This product is a Design for Sustainability (DfS) developed product, which belongs to one of the four categories of greener alternatives. Click here to view its DfS scorecard.
Immunogen
A synthesized peptide corresponding to a sequence within amino acids 350-471 of human MLKL [NP_001135969.1].
Other Notes
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Physical form
Solution in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
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