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关于此项目
经验公式(希尔记法):
C24H30O14
化学文摘社编号:
分子量:
542.49
NACRES:
NA.25
UNSPSC Code:
12352200
MDL number:
InChI
1S/C24H30O14/c1-3-11-12(4-5-35-21(32)10-6-14(26)17(28)15(27)7-10)13(22(33)34-2)9-36-23(11)38-24-20(31)19(30)18(29)16(8-25)37-24/h3,6-7,9,11-12,16,18-20,23-31H,1,4-5,8H2,2H3/t11-,12+,16+,18+,19-,20+,23+,24-/m0/s1
InChI key
SMTKSCGLXONVGL-ZEIULZLQSA-N
form
solid
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
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General description
Natural product derived from plant source.
Biochem/physiol Actions
Cornuside is a secoiridoid glucoside with anti-inflammatory properties through the downregulation of iNOS and COX-2 via NF-kB inhibition.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Wang-Lin Jiang et al.
Pharmacology, 84(3), 162-170 (2009-08-22)
Cornuside, a secoiridoid glucoside compound, was isolated from the fruit of Cornus officinalis Sieb. et Zucc. The present study elucidates the effects of cornuside on cultured rat cortical neuron damage induced by oxygen-glucose deprivation. The results show that cornuside treatment
Yun Ho Choi et al.
Biological & pharmaceutical bulletin, 34(7), 959-966 (2011-07-02)
Cornuside, a secoiridoid glucoside compound, was isolated from the fruit of Cornus officinalis SIEB. et ZUCC. Cornuside has been reported to possess immunomodulatory and anti-inflammatory activities. However, the effects and mechanism of action of cornuside in inflammation have not been
S P Zhao et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 27(11), 845-848 (1992-01-01)
A new bisiridoid glucoside named cornuside was isolated from the fruits of Cornus officinalis Sieb et Zucc. The structure of cornuside has been established by spectroscopic methods (IR, MS, 1HNMR, 13CNMR).
Shun Zong Song et al.
Bioscience, biotechnology, and biochemistry, 75(4), 656-661 (2011-04-23)
This study elucidated the effects of cornuside on carbon tetrachloride (CCl₄)-induced hepatotoxicity. Rats were treated intraperitoneally with 0.5 mL/kg of CCl₄. Sixteen h after CCl₄ treatment, the levels of serum aminotransferases, tumor necrosis factor-α (TNF-α), and lipid peroxidation were significantly
Dae Gill Kang et al.
Planta medica, 73(14), 1436-1440 (2007-10-11)
Cornuside is a bisiridoid glucoside compound isolated from the fruit of CORNUS OFFICINALIS Sieb. et Zucc. (Cornaceae). In the present study, we investigated the effect of cornuside on vascular tone in rat aortic tissue. Cornuside induced a concentration-dependent relaxation of
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