SMB00379
Schisantherin A
≥98% (HPLC)
别名:
Gomisin C, Schizantherin A, Wuweizi ester A
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关于此项目
经验公式（希尔记法）:
C30H32O9
化学文摘社编号:
分子量:
536.57
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.25
SMILES string
CC1(O)C(C)CC2=CC(OCO3)=C3C(OC)=C2C4=C(C=C(OC)C(OC)=C4OC)C1OC(C5=CC=CC=C5)=O
InChI
1S/C30H32O9/c1-16-12-18-13-21-25(38-15-37-21)26(35-5)22(18)23-19(14-20(33-3)24(34-4)27(23)36-6)28(30(16,2)32)39-29(31)17-10-8-7-9-11-17/h7-11,13-14,16,28,32H,12,15H2,1-6H3
InChI key
UFCGDBKFOKKVAC-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
−20°C
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Biochem/physiol Actions
Schisantherin A is a lignan isolated from the fruits of Schisandra chinesi.
Schisantherin A is a mechanism-based inhibitor that competitively inhibits and irreversibly inactivates CYP3A4.
Schisantherin A (StA) has neuroprotective activity and could be potential candidate for the treatment of neuron loss in neurodegenerative diseases including Parkinson′s disease. It inhibits tumor progression and could be a potential drug target for cancer treatment. StA blocks ATP-binding cassette transporters and restores the levels of anti-cancer drugs in cancer cells. It also has anti-inflammatory property.
Schisantherin A (StA) has neuroprotective activity and could be potential candidate for the treatment of neuron loss in neurodegenerative diseases including Parkinson′s disease. It inhibits tumor progression and could be a potential drug target for cancer treatment. StA blocks ATP-binding cassette transporters and restores the levels of anti-cancer drugs in cancer cells. It also has anti-inflammatory property.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Schisantherin A suppresses interleukin-1β-induced inflammation in human chondrocytes via inhibition of NF-κB and MAPKs activation.
Liao S, et al.
European Journal of Pharmacology, 780, 65-70 (2016)
Discovery of novel anti-parkinsonian effect of schisantherin A in in vitro and in vivo.
Sa F, et al.
Neuroscience Letters, 593, 7-12 (2015)
Lignans from Schisandra sphenathera Rehd. et Wils. and semisynthetic schisantherin A analogues: absolute configuration, and their estrogenic and anti-proliferative activity.
Liu H W, et al.
European Journal of Medicinal Chemistry, 59, 265-273 (2013)
Bin Li et al.
Experimental animals, 67(4), 451-461 (2018-05-29)
Schisantherin A (SinA), one of the most abundant active ingredients of Schisandra chinensis, was reported to protect and benefit the liver, however, its effect on alcohol-induced liver injury (ALI) was still not clear. In the present study, an ALI mice
Schisandra Chinensis-derived antioxidant activities in `Sheng Mai San?a compound formulation, in vivo and in vitro.
Ko K M, et al.
Phytotherapy Research, 9(3), 203-206 (1995)
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