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Merck
CN

SMB00606

Sigma-Aldrich

地红霉素

≥96%

别名:

[9S(R)]-9-脱氧-11-脱氧-9,11-[亚氨[2-(2-甲氧基乙氧基)亚乙基]氧]红霉素；LY-237216

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关于此项目

经验公式（希尔记法）:
C42H78N2O14
化学文摘社编号:
62013-04-1
分子量:
835.07
MDL编号:
MFCD00865041
UNSPSC代码:
41116107
PubChem化学物质编号:
329825077

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质量水平

200

方案

≥96%

表单

powder

储存条件

(Keep container tightly closed in a dry and well-ventilated place.)

颜色

white to off-white

抗生素抗菌谱

Gram-negative bacteria

作用机制

protein synthesis | interferes

储存温度

2-8°C

SMILES字符串

CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C4N[C@@H](COCCOC)OC([C@H]4C)[C@]1(C)O

InChI

1S/C42H78N2O14/c1-15-29-42(10,49)37-24(4)32(43-30(56-37)21-52-17-16-50-13)22(2)19-40(8,48)36(58-39-33(45)28(44(11)12)18-23(3)53-39)25(5)34(26(6)38(47)55-29)57-31-20-41(9,51-14)35(46)27(7)54-31/h22-37,39,43,45-46,48-49H,15-21H2,1-14H3/t22-,23-,24+,25+,26-,27+,28+,29-,30-,31+,32+,33-,34+,35+,36-,37-,39+,40-,41+,42-/m1/s1

InChI key

WLOHNSSYAXHWNR-KZYCBHIHSA-N

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生化/生理作用

Dirithromycin is a macrolide antibiotic. It is a prodrug of erythromycylamine that has outstanding activity against Campylobacter. Dirithromycin is a group 3 agent with respect to its interaction with cytochrome P450 (CYP) isoform 3A4, as it interferes poorly with CYP3A4 in vitro and generally does not alter drug metabolism in vivo.

包装

1G

制备说明

When dissolving dirithromycin in organic solvents, first purge the solvent with inert gas.

To prepare in aqueous buffer, dirithromycin should first be dissolved in ethanol and then diluted with aqueous buffer. The solution is stable for one day.

Dirithromycin is soluble in ethanol at approximately 20 mg/mL, DMF at approximately 10 mg/mL, and DMSO at approximately 15 mg/mL.

其他说明

Keep container tightly closed in a dry and well-ventilated place.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H317

预防措施声明

P280

危险分类

Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
096M4089V
13160712

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Comparative in vitro activities of new 14-, 15-, and 16-membered macrolides.
Hardy DJ, Hensey DM, Beyer JM, Vojtko C, McDonald EJ, Fernandes PB.
Antimicrobial Agents and Chemotherapy, 32(11), 1710-1719 (1988)
Macrolide - induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: an update focused on clarithromycin, azithromycin and dirithromycin.
Westphal JF
British Journal of Clinical Pharmacology, 50(4), 285-295 (2000)

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