Name: AI-1
Brand: SIGMA

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About This Item

经验公式（希尔记法）:

C₁₃H₁₂ClNO₃

CAS Number:

75483-04-4

分子量:

265.69

MDL编号:

MFCD00634787

UNSPSC代码:

12352200

PubChem化学物质编号:

329825085

NACRES:

NA.77

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方案

≥98% (HPLC)

表单

powder

颜色

white to tan

溶解性

DMSO: ≥15 mg/mL

储存温度

2-8°C

SMILES字符串

ClC(C1=C(N2C)C=CC=C1)=C(C(OCC)=O)C2=O

InChI

1S/C13H12ClNO3/c1-3-18-13(17)10-11(14)8-6-4-5-7-9(8)15(2)12(10)16/h4-7H,3H2,1-2H3

InChI key

XUJQDJGGHFNYDY-UHFFFAOYSA-N

生化/生理作用

AI-1 positively regulates antioxidant response element (ARE)-driven gene transcription through the activation of Nuclear factor E2-related factor 2 (Nrf2), an ARE-binding transcription factor.

AI-1 promotes Nrf2 activation via the covalent modification of Kelch-like ECH-associated protein 1 (Keap1), a negative regulator of Nrf2. Biochemical studies indicate that an aromatic chloride present within the AI-1 molecule undergoes a nucleophilic aromatic substitution reaction with cysteine thiols of Keap1.