SML0023
5-Iodo-A-85380 dihydrochloride hydrate
≥98% (HPLC)
别名:
3-((2S)-2-Azetidinylmethoxy)-5-iodo-pyridine dihydrochloride hydrate
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关于此项目
经验公式（希尔记法）:
C9H11IN2O · 2HCl · xH2O
化学文摘社编号:
分子量:
363.02 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
InChI key
DCVONLXGZUKNSI-CZDIJEQGSA-N
SMILES string
O.Cl.Cl.Ic1cncc(OC[C@@H]2CCN2)c1
InChI
1S/C9H11IN2O.2ClH.H2O/c10-7-3-9(5-11-4-7)13-6-8-1-2-12-8;;;/h3-5,8,12H,1-2,6H2;2*1H;1H2/t8-;;;/m0.../s1
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to tan
solubility
H2O: ≥22 mg/mL
storage temp.
−20°C
Application
5-Iodo-A-85380 dihydrochloride hydrate may be used in nicotinic acetylcholine receptor-mediated signaling studies.
Biochem/physiol Actions
5-Iodo-A-85380 increases the influx of extracellular Ca+2 in rat cortical neurons and exhibits protective effects against glutamate-induced neurotoxicity. Studies reveal that it also activates α6β2 nicotinic acetylcholine receptors.
5-Iodo-A-85380 is a highly selective α4β2 nicotinic receptor agonist. The Ki values for binding to the human and rat receptors are 12 and 10 pM, respectively.
Highly selective α4β2 nicotinic receptor agonist
Features and Benefits
This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Marwa Y Sallam et al.
European journal of pharmacology, 834, 36-44 (2018-07-17)
The cholinergic antiinflammatory pathway favorably influences end organ damage induced by inflammatory conditions. Here, we hypothesized that α7 and/or α4β2-nicotinic acetylcholine receptors (nAChRs) protect against cardiovascular and autonomic imbalances induced by endotoxemia in rats. We assessed dose-effect relationships of i.v.
Adrian J Mogg et al.
Neuropharmacology, 47(6), 848-859 (2004-11-06)
The novel compound 5-iodo-A-85380 binds with higher affinity to alpha4beta2* nicotinic acetylcholine receptors (nAChR), compared with other nAChR subtypes (Mukhin et al., 2000). In the present study, we have confirmed that in competition binding assays for three major nAChR subtypes
Masashi Ueda et al.
Brain research, 1199, 46-52 (2008-02-14)
5-iodo-3-(2(S)-azetidinylmethoxy)pyridine (5-iodo-A-85380, 5IA) has very high affinity and selectivity to nicotinic acetylcholine receptor (nAChR) alpha 4 beta 2 subtype, and a relative safe profile. To assess whether 5IA has neuroprotective properties, we examined the effect of 5IA on glutamate (Glu)-induced
Helena Montanuy et al.
Orphanet journal of rare diseases, 15(1), 170-170 (2020-07-02)
Fanconi anemia is a rare disease clinically characterized by malformations, bone marrow failure and an increased risk of solid tumors and hematologic malignancies. The only therapies available are hematopoietic stem cell transplantation for bone marrow failure or leukemia, and surgical
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