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About This Item

经验公式(希尔记法):
C9H11IN2O · 2HCl · xH2O
CAS Number:
分子量:
363.02 (anhydrous basis)
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77
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方案

≥98% (HPLC)

表单

powder

储存条件

desiccated

颜色

white to tan

溶解性

H2O: ≥22 mg/mL

储存温度

−20°C

SMILES字符串

O.Cl.Cl.Ic1cncc(OC[C@@H]2CCN2)c1

InChI

1S/C9H11IN2O.2ClH.H2O/c10-7-3-9(5-11-4-7)13-6-8-1-2-12-8;;;/h3-5,8,12H,1-2,6H2;2*1H;1H2/t8-;;;/m0.../s1

InChI key

DCVONLXGZUKNSI-CZDIJEQGSA-N

应用

5-Iodo-A-85380 dihydrochloride hydrate may be used in nicotinic acetylcholine receptor-mediated signaling studies.

生化/生理作用

5-Iodo-A-85380 increases the influx of extracellular Ca+2 in rat cortical neurons and exhibits protective effects against glutamate-induced neurotoxicity. Studies reveal that it also activates α6β2 nicotinic acetylcholine receptors.
5-Iodo-A-85380 is a highly selective α4β2 nicotinic receptor agonist. The Ki values for binding to the human and rat receptors are 12 and 10 pM, respectively.
Highly selective α4β2 nicotinic receptor agonist

特点和优势

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

象形图

CorrosionExclamation mark

警示用语:

Danger

危险声明

危险分类

Acute Tox. 4 Oral - Eye Dam. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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