SML0028
FR-171113
≥98% (HPLC)
别名:
FR-171113, 2-[3-(4-chlorophenyl)-2-[(2,4-dichlorobenzoyl)imino]-4-oxo-5-thiazolidinylidene]-acetic acid, methyl ester
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C19H11Cl3N2O4S
化学文摘社编号:
分子量:
469.73
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.25
SMILES string
COC(=O)\C=C1\SC(=N\C(=O)c2ccc(Cl)cc2Cl)\N(C1=O)c3ccc(Cl)cc3
InChI
1S/C19H11Cl3N2O4S/c1-28-16(25)9-15-18(27)24(12-5-2-10(20)3-6-12)19(29-15)23-17(26)13-7-4-11(21)8-14(13)22/h2-9H,1H3/b15-9+,23-19+
InChI key
SDGLYCKTPKZBGI-MSDDKZNZSA-N
assay
≥98% (HPLC)
form
powder
solubility
DMSO: ≥5 mg/mL
storage temp.
2-8°C
Biochem/physiol Actions
FR-171113 is a Thrombin receptor antagonist
FR171113 was the first non-peptide antagonist of the Protease Activated Receptor-1 (PAR1), also termed thrombin receptor. FR171113 inhibits either thrombin or TRAP-6-induced platelet aggregation (IC50 = 290 and 150 nM, respectively). The compound does not affect the protease activity of thrombin or clotting time.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Carl J May et al.
American journal of physiology. Renal physiology, 317(4), F913-F921 (2019-07-25)
The specific pathogenesis of idiopathic nephrotic syndrome (NS) is poorly understood, and the role of immune mediators remains contentious. However, there is good evidence for the role of a circulating factor, and we recently postulated circulating proteases as candidate factors.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持