登录查看公司和协议定价
About This Item
经验公式（希尔记法）:
C13H15NO2
CAS Number:
分子量:
217.26
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
质量水平
方案
≥98% (HPLC)
表单
powder
旋光性
[α]/D -980 to -1015 (C=1, MeOH)
颜色
yellow
溶解性
DMSO: ≥25 mg/mL
储存温度
2-8°C
SMILES字符串
O=C1O[C@@]23C[C@@H](C=CC2=C1)N4CCCC[C@H]34
InChI
1S/C13H15NO2/c15-12-7-9-4-5-10-8-13(9,16-12)11-3-1-2-6-14(10)11/h4-5,7,10-11H,1-3,6,8H2/t10-,11-,13+/m1/s1
InChI key
SWZMSZQQJRKFBP-WZRBSPASSA-N
正在寻找类似产品? 访问 产品对比指南
应用
Securinine was used as a standard in the synthesis of the members of Securinega alkaloid family.
生化/生理作用
Securinine is a GABAA receptor antagonist which has been found to increase p73 protein expression
Securinine is an alkaloid widely in traditional folk medicine. Long known as a GABAA antagonist, securinine was recently found to up-regulate p53 protein and to modulate the related family member p73 protein in a p53-dependent fashion, inducing p73 in the HCT116 p53(-) cells and down-regulating it in the p53(+) cells. Induction of proapoptotic protein p73 only in p53 cells could be used to target cancer cells preferentially. Securinine has been found to induce p53-independent, p73-dependent apoptosis in RKO colon cancer cells.
特点和优势
This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持