SML0058
CGP 39551
≥98% (HPLC)
别名:
CGP 39551, (E)-(±)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid ethyl ester
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关于此项目
经验公式（希尔记法）:
C8H16NO5P
化学文摘社编号:
分子量:
237.19
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
H2O: 15 mg/mL, clear
储存温度
2-8°C
SMILES字符串
CCOC(=O)C(N)\C=C(/C)CP(O)(O)=O
InChI
1S/C8H16NO5P/c1-3-14-8(10)7(9)4-6(2)5-15(11,12)13/h4,7H,3,5,9H2,1-2H3,(H2,11,12,13)/b6-4+
InChI key
OKDOWCKDTWNRCB-GQCTYLIASA-N
应用
CGP 39551 may be used in cell signaling studies.
生化/生理作用
CGP 39551 is a competitive NMDA antagonist and anticonvulsant.
CGP 39551 is an orally active competitive NMDA antagonist and anticonvulsant.
CGP 39551 produces excitatory effects and causes psychotomimetic effects in humans.
特点和优势
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
警示用语：
Danger
危险声明
预防措施声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
S J Dunworth et al.
Psychopharmacology, 136(3), 308-310 (1998-05-05)
Mice were treated either with diazepam (15 mg/kg s.c. in oil), for 21 days, or for 3x7-day periods interspersed with two 72-h drug-free periods. Convulsant thresholds to pentylentetrazole infused into the tail vein 72 h following the final chronic treatment
P González et al.
European journal of pharmacology, 332(3), 257-262 (1997-08-13)
The effects of the non-competitive antagonists of the glutamate complex receptor, dizocilpine (MK 801) and ketamine and of the competitive antagonist CGP 39551 were examined on the induction of tolerance to morphine, the development of physical dependence and the expression
R D'Hooge et al.
Fundamental & clinical pharmacology, 13(1), 67-74 (1999-02-23)
The effects of CGP 37849 [DL-(E)-2-amino-4-methyl-5-phosphono-3-pentenoate] and its ethylester CGP 39551 on whole-cell currents evoked by the endogenous excitatory amino acids, L-glutamate and L-aspartate, were studied in cultured mouse spinal cord neurones. Although CGP 37849 was the more potent compound
W Löscher et al.
The Journal of pharmacology and experimental therapeutics, 256(2), 432-440 (1991-02-01)
The orally active competitive N-methyl-D-aspartate (NMDA) receptor antagonists CGP 37849 (DL-[E]-2-amino-4-methyl-5-phosphono-3-pentenoic acid) and its ethyl ester CGP 39551 were evaluated in amygdala-kindled rats, a model for complex partial and secondarily generalized seizures. Anticonvulsant and behavioral effects of these novel compounds
B Schilström et al.
Neuroscience, 125(4), 957-964 (2004-05-04)
In the present study, using single cell recordings in vivo and intracellular recordings in vitro from midbrain slices, the role of N-methyl-d-aspartate (NMDA) receptor signaling on firing activity in ventral tegmental area dopamine neurons elicited by nicotine was investigated in
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