SML0058
CGP 39551
≥98% (HPLC)
别名:
CGP 39551, (E)-(±)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid ethyl ester
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关于此项目
经验公式（希尔记法）:
C8H16NO5P
化学文摘社编号:
分子量:
237.19
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
InChI
1S/C8H16NO5P/c1-3-14-8(10)7(9)4-6(2)5-15(11,12)13/h4,7H,3,5,9H2,1-2H3,(H2,11,12,13)/b6-4+
SMILES string
CCOC(=O)C(N)\C=C(/C)CP(O)(O)=O
InChI key
OKDOWCKDTWNRCB-GQCTYLIASA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 15 mg/mL, clear
storage temp.
2-8°C
Application
CGP 39551 may be used in cell signaling studies.
Biochem/physiol Actions
CGP 39551 is a competitive NMDA antagonist and anticonvulsant.
CGP 39551 is an orally active competitive NMDA antagonist and anticonvulsant.
CGP 39551 produces excitatory effects and causes psychotomimetic effects in humans.
Features and Benefits
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Barbara Monti et al.
The European journal of neuroscience, 16(8), 1490-1498 (2002-10-31)
During both in vivo and in vitro development, cerebellar granule cells depend on the activity of the NMDA glutamate receptor subtype for survival and full differentiation. With the present results, we demonstrate that CREB activation, downstream of the NMDA receptor
J J Kim et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(10), 4750-4753 (1996-05-14)
Behavioral stress has detrimental effects on subsequent cognitive performance in many species, including humans. For example, humans exposed to stressful situations typically exhibit marked deficits in various learning and memory tasks. However, the underlying neural mechanisms by which stress exerts
Agnès Gruart et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(4), 1077-1087 (2006-01-27)
One of the brain sites more directly related with learning and memory processes is the hippocampus. We recorded, in conscious mice, the activity-dependent changes taking place at the hippocampal CA3-CA1 synapse during the acquisition, extinction, recall, and reconditioning of an
W Zajaczkowski et al.
Neuropharmacology, 36(7), 961-971 (1997-07-01)
In general, N-methyl-D-aspartate (NMDA) receptor antagonists inhibit learning and long term potentiation (LTP). However, it has been suggested that direct tonic, i.e. non-temporal, activation of NMDA receptors, in contrast to learning, may lead to an increase in synaptic "noise" and
M M Marcus et al.
Neuropharmacology, 40(4), 482-490 (2001-03-16)
The effects of acute intravenous administration of the non-competitive NMDA receptor antagonists, phencyclidine (PCP), dizocilpine (MK-801; (+)-5-methyl-10,11-dihydroxy-5H-dibenzo(a,b)cyclohepten-5,10-imine), and the competitive NMDA receptor antagonist CGP 39551 (DL-(E)-2-amino-4-methyl-5-phosphono-3-pentanoic acid) on extracellular dopamine concentrations were analyzed in the shell and core subdivisions of
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