SML0069
NSC 33994
≥98% (HPLC)
别名:
(E)-4,4′-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]-phenol (9CI), 4,4′-(3E)-Hex-3-ene-3,4-diylbis{2-[(diethylamino)methyl]phenol}, G6
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关于此项目
经验公式（希尔记法）:
C28H42N2O2
化学文摘社编号:
分子量:
438.65
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
方案
≥98% (HPLC)
表单
powder
颜色
white to tan
溶解性
DMSO: ≥25 mg/mL
储存温度
2-8°C
SMILES字符串
CCN(CC)Cc1cc(ccc1O)C(\CC)=C(/CC)c2ccc(O)c(CN(CC)CC)c2
InChI
1S/C28H42N2O2/c1-7-25(21-13-15-27(31)23(17-21)19-29(9-3)10-4)26(8-2)22-14-16-28(32)24(18-22)20-30(11-5)12-6/h13-18,31-32H,7-12,19-20H2,1-6H3/b26-25+
InChI key
QFNJFVBKASKGEU-OCEACIFDSA-N
应用
NSC 33994 may be used in Jak2-mediated cell signaling studies.
生化/生理作用
NSC 33994 is a potent and specific Jak2 inhibitor that inhibits a notorious mutation, Jak2-V617F, found in large number of myeloproliferative neoplasms.
Potent and specific Jak2 inhibitor effective against Jak2-V617F mutation
特点和优势
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the JAKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
Zhen Wang et al.
Scientific reports, 8(1), 9509-9509 (2018-06-24)
The exon junction complex (EJC) deposited on spliced mRNAs, plays a central role in the post-transcriptional gene regulation and specific gene expression. The EJC core complex is associated with multiple peripheral factors involved in various post-splicing events. Here, using recombinant
Kimberly McCoy et al.
ACS nano, 12(4), 3541-3550 (2018-03-21)
Bottom-up construction of mesoscale materials using biologically derived nanoscale building blocks enables engineering of desired physical properties using green production methods. Virus-like particles (VLPs) are exceptional building blocks due to their monodispersed sizes, geometric shapes, production ease, proteinaceous composition, and
Yuehui Wang et al.
Methods (San Diego, Calif.), 173, 32-43 (2019-06-22)
Influx evidences show that red long non-coding RNAs (lncRNAs) play important roles in various critical biological processes, and they afffect the development and progression of various human diseases. Therefore, it is necessary to precisely identify the lncRNA-disease associations. The identification
Tetsushi Yoshikawa et al.
Journal of medical virology, 91(6), 1008-1013 (2019-01-29)
The main aims of the present study were to elucidate the systemic group A rotavirus (RVA) infection and to clarify the genetic changes of persistent virus in the X-linked severe combined immunodeficiency (SCID) patient. RotaTeq vaccine (RV5) genotype-specific real-time reverse
S Khademvatan et al.
Journal of helminthology, 93(2), 131-138 (2018-04-03)
Cystic echinococcosis (CE) caused by Echinococcus granulosus sensu lato (s.l.) is a significant zoonosis, especially in developing countries of the Middle East, with many studies focusing on CE genotypes in Iran. We performed a systematic review to determine the exact
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Discover Bioactive Small Molecules for Kinase Phosphatase Biology
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