SML0096
朱砂酸
≥98% (HPLC), mGlu4R agonist, powder
别名:
2-氨基-3-氧代-3H-吩恶嗪-1,9-二羧酸, 朱砂精酸
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关于此项目
经验公式（希尔记法）:
C14H8N2O6
化学文摘社编号:
分子量:
300.22
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.25
MDL number:
产品名称
朱砂酸, ≥98% (HPLC)
SMILES string
NC1=C(C(O)=O)C2=Nc3c(OC2=CC1=O)cccc3C(O)=O
InChI
1S/C14H8N2O6/c15-10-6(17)4-8-12(9(10)14(20)21)16-11-5(13(18)19)2-1-3-7(11)22-8/h1-4H,15H2,(H,18,19)(H,20,21)
InChI key
FSBKJYLVDRVPTK-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
red to very dark red
solubility
DMSO: ≥4 mg/mL
storage temp.
2-8°C
Quality Level
Application
朱砂酸可用于研究犬尿氨酸代谢途径的成分的功能。它可用于研究其作为代谢型谷氨酸受体（mGlu4R特异性）激动剂的作用。
Biochem/physiol Actions
半胱天冬酶诱导剂；mGlu4R激动剂
半胱天冬酶诱导剂；mGlu4R激动剂
朱砂精酸（CA）在犬尿氨酸途径的启动与用于预防神经炎症的免疫耐受之间建立联系。
朱砂精酸（CA）在犬尿氨酸途径的启动与用于预防神经炎症的免疫耐受之间建立联系。
朱砂精酸是色氨酸的犬尿氨酸途径代谢产物，由3-羟基邻氨基苯甲酸氧化产生。 朱砂精酸导致线粒体呼吸和细胞凋亡的丧失，并且还被证明是mGlu4R特异性激动剂。
Features and Benefits
该化合物是细胞凋亡研究的推荐产品。点击此处，了解更多精选的细胞凋亡产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问sigma.com/discover-bsm。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Hideaki Iizuka et al.
Biomedical chromatography : BMC, 24(3), 231-234 (2009-07-25)
A fluorimetric detection method for one of the tryptophan metabolites, cinnabarinic acid (CA), which has recently been reported to have the ability to induce apoptosis in thymocytes, was developed using o-tolyl hydrazine (TH) as the derivatization reagent. The carbonyl group
H Ogawa et al.
Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 364(11), 1507-1518 (1983-11-01)
The formation of cinnabarinate in the presence of manganese ions and catalase was investigated spectrophotometrically. The absorption peak of cinnabarinate at 460 nm appeared only in a reaction system containing manganese ions and catalase. If catalase was omitted, a new
U Temp et al.
Applied and environmental microbiology, 65(2), 389-395 (1999-01-30)
When glucose is the carbon source, the white rot fungus Pycnoporus cinnabarinus produces a characteristic red pigment, cinnabarinic acid, which is formed by laccase-catalyzed oxidation of the precursor 3-hydroxyanthranilic acid. When P. cinnabarinus was grown on media containing cellobiose or
Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in mice.
Fazio F, et al.
Neuropharmacology, 81, 237-243 (2014)
S Christen et al.
Biochemistry, 31(34), 8090-8097 (1992-09-01)
Since 3-hydroxyanthranilic acid (3HAA), an oxidation product of tryptophan metabolism, is a powerful radical scavenger [Christen, S., Peterhans, E., & Stocker, R. (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 2506], its reaction with peroxyl radicals was investigated further. Exposure to
商品
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
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