SML0107
吡罗司特钾
≥98% (HPLC)
别名:
9-Methyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one potassium salt; BMY 26517
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关于此项目
经验公式（希尔记法）:
C10H7N6O·K
化学文摘社编号:
分子量:
266.30
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
SMILES string
[K+].CC1=CC=CN2C(=O)C(=CN=C12)c3nnn[n-]3
InChI
1S/C10H7N6O.K/c1-6-3-2-4-16-9(6)11-5-7(10(16)17)8-12-14-15-13-8;/h2-5H,1H3;/q-1;+1
InChI key
NMMVKSMGBDRONO-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
light yellow to green-yellow
solubility
H2O: ≥18 mg/mL
originator
Bristol-Myers Squibb
storage temp.
2-8°C
Biochem/physiol Actions
Pemirolast potassium is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent. It Inhibits chemical mediator release from tissue mast cells and has recently also been shown to inhibit the release of peptides including substance P, neurokinin (NK) A, and calcitonin gene-related peptide (CGRP) from sensory nerves. It has been used for the treatment of allergic conjunctivitis prophylaxis of for pulmonary hypersensitivity reactions to drugs such as paclitaxel
Pemirolast potassium is a histamine H1 antagonist and mast cell stabilizer; Inhibitor of chemical mediator release from tissue mast cells; antiallergic agent
Features and Benefits
This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
M Teresa Magone et al.
Cornea, 25(3), 364-367 (2006-04-25)
To report a case of peripheral interstitial keratitis in a patient with mastocytosis. Clinical case description and immunohistologic examination of biopsied ocular tissue. A 22-year-old woman with biopsy-proven urticaria pigmentosa, a subset of mastocytosis, presented with an active peripheral interstitial
Amber M Young et al.
Journal of pharmaceutical sciences, 95(4), 717-725 (2006-02-25)
A tetrazole ring is often used in drug discovery as a replacement for the carboxylic acid group. Previous work indicates that compounds containing a tetrazole moiety show asymmetric permeability in Caco-2 cells characteristic of an efflux transporter substrate. The aim
Yoshinori Itoh et al.
Neuropharmacology, 46(6), 888-894 (2004-03-23)
The effects of anti-allergic agents on the hypersensitivity reactions to paclitaxel, an anti-cancer agent, were examined in rats. Intravenous injection of paclitaxel (15 mg/kg) caused a marked extravasation of plasma protein in lungs and a transient decrease in arterial partial
N Miyazawa et al.
Journal of cardiovascular pharmacology, 30(2), 157-162 (1997-08-01)
We previously reported that tranilast, an antiallergic agent, reduced intimal thickening after endothelial injury in rats. In this study, to verify whether or not antiallergic agents inhibit intimal thickening, we investigated the effect of pemirolast on intimal thickening after endothelial
H Ohsawa et al.
American heart journal, 136(6), 1081-1087 (1998-12-08)
We recently confirmed that pemirolast potassium, an antiallergic agent, markedly inhibits migration and proliferation of vascular smooth muscle cells. It has also been reported that pemirolast inhibits intimal hyperplasia in animal experiments. To elucidate the preventive effects of pemirolast on
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