SML0107
吡罗司特钾
≥98% (HPLC)
别名:
9-Methyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one potassium salt; BMY 26517
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关于此项目
经验公式（希尔记法）:
C10H7N6O·K
化学文摘社编号:
分子量:
266.30
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
方案
≥98% (HPLC)
表单
powder
颜色
light yellow to green-yellow
溶解性
H2O: ≥18 mg/mL
创始人
Bristol-Myers Squibb
储存温度
2-8°C
SMILES字符串
[K+].CC1=CC=CN2C(=O)C(=CN=C12)c3nnn[n-]3
InChI
1S/C10H7N6O.K/c1-6-3-2-4-16-9(6)11-5-7(10(16)17)8-12-14-15-13-8;/h2-5H,1H3;/q-1;+1
InChI key
NMMVKSMGBDRONO-UHFFFAOYSA-N
生化/生理作用
Pemirolast potassium is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent. It Inhibits chemical mediator release from tissue mast cells and has recently also been shown to inhibit the release of peptides including substance P, neurokinin (NK) A, and calcitonin gene-related peptide (CGRP) from sensory nerves. It has been used for the treatment of allergic conjunctivitis prophylaxis of for pulmonary hypersensitivity reactions to drugs such as paclitaxel
Pemirolast potassium is a histamine H1 antagonist and mast cell stabilizer; Inhibitor of chemical mediator release from tissue mast cells; antiallergic agent
特点和优势
This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
M Teresa Magone et al.
Cornea, 25(3), 364-367 (2006-04-25)
To report a case of peripheral interstitial keratitis in a patient with mastocytosis. Clinical case description and immunohistologic examination of biopsied ocular tissue. A 22-year-old woman with biopsy-proven urticaria pigmentosa, a subset of mastocytosis, presented with an active peripheral interstitial
Yoshinori Itoh et al.
Neuropharmacology, 46(6), 888-894 (2004-03-23)
The effects of anti-allergic agents on the hypersensitivity reactions to paclitaxel, an anti-cancer agent, were examined in rats. Intravenous injection of paclitaxel (15 mg/kg) caused a marked extravasation of plasma protein in lungs and a transient decrease in arterial partial
Kazuhisa Minami et al.
Biological & pharmaceutical bulletin, 28(3), 473-476 (2005-03-04)
The effect of the simultaneous use of 0.025% levocabastine hydrochloride eye drops (levocabastine) and 0.1% pemirolast potassium ophthalmic solution (pemirolast) on experimental allergic conjunctivitis in rats was investigated. Levocabastine and pemirolast significantly inhibited allergic conjunctivitis compared with the control group
N Miyazawa et al.
Journal of cardiovascular pharmacology, 30(2), 157-162 (1997-08-01)
We previously reported that tranilast, an antiallergic agent, reduced intimal thickening after endothelial injury in rats. In this study, to verify whether or not antiallergic agents inhibit intimal thickening, we investigated the effect of pemirolast on intimal thickening after endothelial
Amber M Young et al.
Journal of pharmaceutical sciences, 95(4), 717-725 (2006-02-25)
A tetrazole ring is often used in drug discovery as a replacement for the carboxylic acid group. Previous work indicates that compounds containing a tetrazole moiety show asymmetric permeability in Caco-2 cells characteristic of an efflux transporter substrate. The aim
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