SML0185
NQDI-1
≥98% (HPLC)
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关于此项目
经验公式（希尔记法）:
C19H13NO4
化学文摘社编号:
分子量:
319.31
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
color
orange
InChI
1S/C19H13NO4/c1-2-24-19(23)16-15-10-6-3-4-7-11(10)17(21)12-8-5-9-13(14(12)15)20-18(16)22/h3-9H,2H2,1H3,(H,20,22)
SMILES string
CCOC(=O)C1=C2c3ccccc3C(=O)c4cccc(NC1=O)c24
InChI key
UFJGFNHRMPMALC-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
solubility
DMSO: ≥5 mg/mL (warmed to 60° C)
storage temp.
2-8°C
Quality Level
Application
NQDI-1 用于研究 LPS 诱导的活化以及 ASK1 和 p38 在巨噬细胞产生抗炎细胞因子中的作用。
Biochem/physiol Actions
ASK1 抑制剂
NQDI-1 抑制 caspase-3 的活化，并防止细胞凋亡引起的细胞死亡。它具有神经保护作用，可防止 ROS 诱导的神经元凋亡。
NQDI-1 是凋亡信号调节激酶（ASK1）的抑制剂，Ki = 500 nM。NQDI-1 对 Aurora A 或 ROCK 激酶或几种受体酪氨酸激酶几乎没有抑制活性。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Koji Nomura et al.
Neuroscience letters, 549, 163-167 (2013-06-08)
Reactive oxygen species (ROS) are believed to be involved in many forms of neurodegeneration, including ischaemic infarct damage and Alzheimer's disease. Despite the known involvement of p38 and JNK MAP kinases in mediating apoptosis and cell death in a variety
Xi Huang et al.
International journal of cancer, 146(7), 1963-1978 (2019-08-08)
E3 ubiquitin ligases primarily determine the substrate specificity of the ubiquitin-proteasome system and play an essential role in the resistance to bortezomib in multiple myeloma (MM). Neural precursor cell-expressed developmentally downregulated gene 4-1 (NEDD4-1, also known as NEDD4) is a
So Yeong Cheon et al.
Frontiers in molecular neuroscience, 10, 261-261 (2017-09-01)
Inflammation is implicated in ischemic stroke and is involved in abnormal homeostasis. Activation of the immune system leads to breakdown of the blood-brain barrier and, thereby, infiltration of immune cells into the brain. Upon cerebral ischemia, infiltrated macrophages and microglia
Youguang Luo et al.
Oncotarget, 7(46), 75155-75164 (2016-09-23)
Pancreatic cancer has an extremely grim prognosis, with an overall 5-year survival rate less than 5%, as a result of its rapid metastasis and late diagnosis. To combat this disease, it is crucial to better understand the molecular mechanisms that
Aiko Tanaka et al.
Biochemical and biophysical research communications, 493(1), 468-473 (2017-09-09)
Free fatty acids not only play a role in cell membrane construction and energy production but also exert diverse cellular effects through receptor and non-receptor mechanisms. Moreover, epidemiological and clinical studies have so far suggested that polyunsaturated fatty acids (PUFAs)
商品
The mitogen-activated protein kinase (MAPK) family consists of stress-activated (SAPK) and MAPKs. Learn about their network of signal transduction cascades that mediate cellular responses to a diverse range of stimuli.
丝裂原活化蛋白激酶(MAPK)家族由应激激活(SAPK)和丝裂原活化(MAPK)的蛋白激酶组成。了解它们介导细胞多种刺激反应的信号转导级联网络。
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