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SML0192

Cyclosporin C

≥95% (HPLC), from Acremonium luzulae

别名:

7-Threonine-cyclosporin A, Cyclosporine C

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关于此项目

经验公式（希尔记法）:
C62H111N11O13
化学文摘社编号:
59787-61-0
分子量:
1218.61
UNSPSC Code:
12352200
NACRES:
NA.77
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biological source

Acremonium luzulae

assay

≥95% (HPLC)

solubility

DMSO: ≥10 mg/mL, H2O: insoluble, hexane: insoluble

antibiotic activity spectrum

fungi

mode of action

enzyme | inhibits

storage temp.

−20°C

InChI

1S/C62H111N11O13/c1-25-26-27-39(14)52(76)51-56(80)66-49(42(17)74)60(84)67(18)32-47(75)68(19)43(28-33(2)3)55(79)65-48(37(10)11)61(85)69(20)44(29-34(4)5)54(78)63-40(15)53(77)64-41(16)57(81)70(21)45(30-35(6)7)58(82)71(22)46(31-36(8)9)59(83)72(23)50(38(12)13)62(86)73(51)24/h25-26,33-46,48-52,74,76H,27-32H2,1-24H3,(H,63,78)(H,64,77)(H,65,79)(H,66,80)/b26-25+/t39-,40+,41-,42-,43+,44+,45+,46+,48+,49+,50+,51+,52-/m1/s1

InChI key

JTOKYIBTLUQVQV-QRVTZXGZSA-N

Application

Cyclosporin C may be used to study the cell signaling involved in autoimmune disorders.

Biochem/physiol Actions

Cyclosporins are a family of neutral, highly lipophilic, cyclic undecapeptides containing some unusual amino acids.
Cyclosporins are a family of neutral, highly lipophilic, cyclic undecapeptides containing some unusual amino acids. Cyclosporin A (CsA) is the main representative of cyclosporins. It has antifungal activity and is the strongest immunosuppressive compound discovered so far. Cyclosporin C has the same activity with reduced potency. CsA has potent anti-Hepatitis C Virus (HCV) activity towards both HCV replicons. Cyclophilins are intracellular proteins, highly conserved, involved in cis-trans isomerization of peptidyl-prolyl bonds and protein folding which bind cyclosporins and as a complex inhibit the activity of calcineurin, a phosphatase necessary for T-cell activation. Cyclosporin is therefore used for treating autoimmune disorders such as rheumatoid arthritis, systemic lupus erythematosus (SLE), and psoriasis.

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
064M4124V
14111012
101M4097V

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Y Sugiura et al.
Medical mycology, 41(3), 241-247 (2003-09-11)
Two strains of soil-borne Fusarium solani, both characterized for their ability to produce cyclosporin A and C, were examined for their pathogenicity in severe combined immunodeficiency (SCID) and BALB/c male mice. Intravenous (i.v.) infections with F. solani conidia were performed.
En Li et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 43(4), 361-365 (2008-07-31)
To study the effect of P-glycoprotein (P-gp) on the absorption of buagafuran in ileum, the concentration of buagafuran in Caco-2 cells, rat averted intestinal sacs and recirculating perfusion were determined by UV-HPLC method. Verapamil and cyclospirin A (CsA) were used
S el Rouby et al.
Clinical and experimental immunology, 89(1), 136-142 (1992-07-01)
Cyclosporin (CsA) is an immunosuppressant which binds to cyclophilin (Cyp). The relationship between Cyp binding and immunosuppression has been questioned since one of the analogs of CsA, N-methyl-L-alanyl6 cyclosporin (methyl-alanyl CsA) binds to Cyp but is not immunosuppressive. We compared
M Nogami et al.
The American review of respiratory disease, 141(5 Pt 1), 1289-1295 (1990-05-01)
The transnasal administration of an extract of the parasite Ascaris suum (Asc) to C57BL/6 mice for 3 wk produced marked eosinophilia in the bronchoalveolar lavage (BAL) fluid. This pulmonary eosinophilia was not accompanied by blood eosinophilia. The oral administration of
Monitoring cyclosporine by HPLC with cyclosporin C as internal standard.
P M Jones et al.
Clinical chemistry, 39(1), 168-168 (1993-01-01)
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