SML0236
ZM 336372
≥98% (HPLC)
别名:
3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]-benzamide
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关于此项目
经验公式（希尔记法）:
C23H23N3O3
化学文摘社编号:
分子量:
389.45
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: >5 mg/mL (warmed)
储存温度
2-8°C
SMILES字符串
CN(C)c1cccc(c1)C(=O)Nc2ccc(C)c(NC(=O)c3ccc(O)cc3)c2
InChI
1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28)
InChI key
PYEFPDQFAZNXLI-UHFFFAOYSA-N
生化/生理作用
ZM-336372 is a potent inhibitor of the MAP kinase c-raf in in vitro assay systems (IC50 = 70 nM). In cell-based experiments, ZM-336372 induces c-raf activation through a novel feedback loop in which inhibition is counterbalanced by reactivation.
ZM-336372 is a potent inhibitor of the MAP kinase c-raf.
警示用语：
Warning
危险声明
危险分类
Aquatic Chronic 4 - Skin Sens. 1B
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
E M Weissinger et al.
British journal of cancer, 91(1), 186-192 (2004-06-10)
Activation of PKA by cAMP agonists, such as 8-Cl-cAMP activation, selectively causes rapid apoptosis in v-abl transformed fibroblasts by inhibiting the Raf-1 kinase. Here we investigated whether 8-Cl-cAMP is useful for the treatment of chronic myelogenous leukaemia (CML), which is
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The extracellular signal regulated kinase (ERK1 and ERK2) pathways are activated by mitogens and play an important role in controlling cell growth and differentiation.
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