SML0236
ZM 336372
≥98% (HPLC)
别名:
3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]-benzamide
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关于此项目
经验公式（希尔记法）:
C23H23N3O3
化学文摘社编号:
分子量:
389.45
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: >5 mg/mL (warmed)
storage temp.
2-8°C
SMILES string
CN(C)c1cccc(c1)C(=O)Nc2ccc(C)c(NC(=O)c3ccc(O)cc3)c2
InChI
1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28)
InChI key
PYEFPDQFAZNXLI-UHFFFAOYSA-N
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Biochem/physiol Actions
ZM-336372 is a potent inhibitor of the MAP kinase c-raf in in vitro assay systems (IC50 = 70 nM). In cell-based experiments, ZM-336372 induces c-raf activation through a novel feedback loop in which inhibition is counterbalanced by reactivation.
ZM-336372 is a potent inhibitor of the MAP kinase c-raf.
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 4 - Skin Sens. 1B
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
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E M Weissinger et al.
British journal of cancer, 91(1), 186-192 (2004-06-10)
Activation of PKA by cAMP agonists, such as 8-Cl-cAMP activation, selectively causes rapid apoptosis in v-abl transformed fibroblasts by inhibiting the Raf-1 kinase. Here we investigated whether 8-Cl-cAMP is useful for the treatment of chronic myelogenous leukaemia (CML), which is
商品
The extracellular signal regulated kinase (ERK1 and ERK2) pathways are activated by mitogens and play an important role in controlling cell growth and differentiation.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML0236-25MG | 04061833222232 |
| SML0236-5MG | 04061833222249 |
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