SML0259
长春质碱
≥95% (HPLC)
别名:
(+)-3,4-Didehydrocoronaridine, (2α,5β,6α,18β)-3,4-Didehydroibogamine-18-carboxylic acid methyl ester, 7-Ethyl-9,10,12,13-tetrahydro-6,9-methano-5H-pyrido[1′,2′:1,2]azepino[4,5-b]indole-6(6aH)-carboxylic acid methyl ester
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关于此项目
经验公式（希尔记法）:
C21H24N2O2
化学文摘社编号:
分子量:
336.43
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥95% (HPLC)
Form:
powder
assay
≥95% (HPLC)
form
powder
optical activity
[α]/D +30 to +38° (c=0.5, CDCl3)
color
white to beige
solubility
DMSO: 5 mg/mL (clear solution; warmed)
shipped in
wet ice
storage temp.
−20°C
SMILES string
CCC1=C[C@@H]2C[N@H]3CCc4c([nH]c5ccccc45)[C@@](C2)([C@@H]13)C(=O)OC
InChI
1S/C21H24N2O2/c1-3-14-10-13-11-21(20(24)25-2)18-16(8-9-23(12-13)19(14)21)15-6-4-5-7-17(15)22-18/h4-7,10,13,19,22H,3,8-9,11-12H2,1-2H3/t13-,19+,21-/m0/s1
InChI key
CMKFQVZJOWHHDV-NQZBTDCJSA-N
Biochem/physiol Actions
Catharanthine is a precursor of the anti-tumor drugs vinblastine and vincristine, formed by dimerization of catharanthine with vindoline. Catharanthine itself is an inhibitor of tubulin self-assembly into microtubules, although not so potent as vinblastine or vincristine. Catharanthine also has anticholinergic activity. It showed muscarinic antagonism at 10 microM and fully inhibited nicotinic receptor mediated diaphragm contractions with an IC50 of 59.6 microM.
Catharanthine is a precursor of the anti-tumor drugs vinblastine and vincristine..Catharanthine is an inhibitor of tubulin self-assembly into microtubules.
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signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Mei-Liang Zhou et al.
Applied microbiology and biotechnology, 88(3), 737-750 (2010-08-18)
Jasmonates and nitric oxide (NO) play important roles in the regulation of the signaling network leading to the biosynthesis of plant secondary metabolites. In this work, we explore the effect of constitutive overexpression of CrORCA3 (octadecanoid-responsive Catharanthus AP2/ERF domain), methyl
Xiaofen Sun et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 34(2), 128-131 (2009-04-24)
Catharanthine content and agronomic traits in major Catharanthus roseus varieties were analyzed. It was found that there existed great difference in catharanthine content and agronomic traits among the varieties. Catharanthine content was the highest in variety Pacifica Polka Dot (PPD)
Mei-Liang Zhou et al.
Applied biochemistry and biotechnology, 166(7), 1674-1684 (2012-02-14)
Catharanthus roseus (L.) G. Don is a plant species known for its production of a variety of terpenoid indole alkaloids, many of which have pharmacological activities. Catharanthine can be chemically coupled to the abundant leaf alkaloid vindoline to form the
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML0259-50MG | 04061833222348 |
| SML0259-10MG | 04061833222331 |