SML0261
SC66
≥98% (HPLC)
别名:
(2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone
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关于此项目
经验公式（希尔记法）:
C18H16N2O
化学文摘社编号:
分子量:
276.33
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
产品名称
SC66, ≥98% (HPLC)
InChI
1S/C18H16N2O/c21-18-16(12-14-4-8-19-9-5-14)2-1-3-17(18)13-15-6-10-20-11-7-15/h4-13H,1-3H2/b16-12+,17-13+
SMILES string
O=C1\C(CCC\C1=C/c2ccncc2)=C\c3ccncc3
InChI key
CYVVJSKZRBZHAV-UNZYHPAISA-N
assay
≥98% (HPLC)
form
powder
color
faintly yellow to dark yellow
solubility
DMSO: ≥5 mg/mL (warmed)
storage temp.
2-8°C
Biochem/physiol Actions
SC66 is a dual function Akt inhibitor.
SC66 is an allosteric inhibitor of Akt that prevents binding of PIP3 to the PH domain. The compound prevents activation of Akt by PIP3, and also facilitates ubiquination and degradation of Akt. SC66 inhibition is maintained against a cancer relevant Akt mutation (E17K) that is resistant to the actions of PIP3K inhibitors. SC66 is active in vivo, and significantly inhibits the ability of HEK293T cells to form colonies in soft agar and tumor growth in nude mice.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
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