SML0300
Aib-1 trifluoroacetate salt
≥98% (HPLC)
别名:
Tyr-Aib-Trp-Phe trifluoroacetate salt
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关于此项目
经验公式（希尔记法）:
C33H37N5O6 · xC2HF3O2
化学文摘社编号:
分子量:
599.68 (free base basis)
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
SMILES string
OC(=O)C(F)(F)F.CC(C)(NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc2cc3ccccc3[nH]2)C(=O)N[C@@H](Cc4ccccc4)C(O)=O
InChI
1S/C33H37N5O6.C2HF3O2/c1-33(2,38-29(40)25(34)16-21-12-14-24(39)15-13-21)32(44)37-27(19-23-18-22-10-6-7-11-26(22)35-23)30(41)36-28(31(42)43)17-20-8-4-3-5-9-20;3-2(4,5)1(6)7/h3-15,18,25,27-28,35,39H,16-17,19,34H2,1-2H3,(H,36,41)(H,37,44)(H,38,40)(H,42,43);(H,6,7)/t25-,27-,28-;/m0./s1
InChI key
NELSAMPJZPTPEG-MDQBHWJISA-N
assay
≥98% (HPLC)
form
lyophilized solid
color
white to beige
shipped in
wet ice
storage temp.
−20°C
Biochem/physiol Actions
Aib-1 is an inhibitor of β-Amyloid oligomerization.
Aib-1 is an inhibitor of β-Amyloid oligomerization. Aib-1 is an endomorphin analog more stable to enzymatic degradation and incorporating the β-breaker 2 aminoisobutyric acid. It interacted with Aβ and markedly inhibited the formation of toxic oligomer and fibril growth using in vitro assays, prevented Aβ toxicity in neuronal PC12 cells, and increased longevity in a fly model of Alzheimer′s disease. Aib-1 activity is thought to be due to multi-mode interactions including aromatic, hydrophobic, and polar contacts with Aβ.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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