SML0302
4-CMTB
≥98% (HPLC)
别名:
4-Chloro-α-(1-methylethyl)-N-2-thiazolyl-benzeneacetamide
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关于此项目
经验公式（希尔记法）:
C14H15ClN2OS
化学文摘社编号:
分子量:
294.80
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: ≥10 mg/mL
storage temp.
2-8°C
SMILES string
CC(C)C(C(=O)Nc1nccs1)c2ccc(Cl)cc2
InChI
1S/C14H15ClN2OS/c1-9(2)12(10-3-5-11(15)6-4-10)13(18)17-14-16-7-8-19-14/h3-9,12H,1-2H3,(H,16,17,18)
InChI key
AZYDQCGCBQYFSE-UHFFFAOYSA-N
Application
4-CMTB has been used as an allosteric agonist for the free fatty acid receptor 2 (FFAR2) in human lung carcinoma (A549) cells for cell viability assay and Influenza A virus (IAV) internalization studies.
Biochem/physiol Actions
4-CMTB is a phenylacetamide compound that acts as an allosteric modulator for the activity of short-chain fatty acid ligand in the FFA2 receptor.
4-CMTB is a potent allosteric agonist of FFA2.
4-CMTB is a potent allosteric agonist of free fatty acid receptor 2 (FFA2).
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Nicola J Smith et al.
Molecular pharmacology, 80(1), 163-173 (2011-04-19)
Allosteric agonists are powerful tools for exploring the pharmacology of closely related G protein-coupled receptors that have nonselective endogenous ligands, such as the short chain fatty acids at free fatty acid receptors 2 and 3 (FFA2/GPR43 and FFA3/GPR41, respectively). We
Sandra Rutting et al.
American journal of physiology. Lung cellular and molecular physiology, 316(1), L157-L174 (2018-11-09)
Short-chain fatty acids (SCFAs), produced as by-products of dietary fiber metabolism by gut bacteria, have anti-inflammatory properties and could potentially be used for the treatment of inflammatory diseases, including asthma. The direct effects of SCFAs on inflammatory responses in primary
Sarah Ducastel et al.
Scientific reports, 10(1), 174-174 (2020-01-15)
The gut microbiota participates in the control of energy homeostasis partly through fermentation of dietary fibers hence producing short-chain fatty acids (SCFAs), which in turn promote the secretion of the incretin Glucagon-Like Peptide-1 (GLP-1) by binding to the SCFA receptors
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML0302-5MG | 04061832824468 |
| SML0302-25MG | 04061832260938 |