SML0323
SMI-4a
≥98% (HPLC)
别名:
(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione, (Z)-5-(3-Trifluoromethylbenzylidene)thiazolidine-2,4-dione
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关于此项目
经验公式（希尔记法）:
C11H6F3NO2S
化学文摘社编号:
分子量:
273.23
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)/b8-5-
SMILES string
FC(F)(F)c1cccc(\C=C2/SC(=O)NC2=O)c1
InChI key
NGJLOFCOEOHFKQ-YVMONPNESA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
SMI-4a is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM for Pim-1 compared to an IC50 of 100 nM for Pim-2 and with little or no activity against a panel of 50 other kinases tested. SMI-4a has been found to inhibit prostate cancer cell growth and induce G1 phase cell-cycle arrest in precursor T-cell lymphoblastic leukemia/lymphoma cell lines.
SMI-4a is a selective ATP-competitive Pim-1 kinase inhibitor.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Yan Lu et al.
Current neurovascular research, 17(4), 471-479 (2020-08-21)
The Inflammatory cytokine, tumor necrosis factor-α (TNF-α), disrupts blood-brain barrier (BBB). Propofol reportedly exerts an anti-inflammatory effect in the central nervous system. We hypothesized that propofol could provide a protective effect against TNF-α-induced disruption in human cerebral microvascular endothelial cells
Rui-Fang Fan et al.
Molecular medicine reports, 16(4), 4603-4612 (2017-08-30)
The development of targeted tyrosine kinase inhibitors (TKIs) has succeeded in altering the course of chronic myeloid leukemia (CML). However, a number of patients have failed to respond or experienced disease relapse following TKI treatment. Proviral integration site for moloney murine
Xinyi Zhang et al.
Molecular immunology, 125, 15-22 (2020-07-04)
PIM1 is serine/threonine protein kinase that is involved in numerous biological processes. Pulmonary fibrosis (PF) is a chronic pathological result of the dysfunctional repair of lung injury without effective therapeutic treatments. In the current study, we investigated whether PIM1 inhibition
Jinxuan Wang et al.
International immunopharmacology, 73, 568-574 (2019-06-17)
PIM kinase is involved in the cellular processes of growth, differentiation and apoptosis. However, the role of PIM1 in lipopolysaccharide (LPS)-induced acute lung injury (ALI) remains largely unknown. A trend of PIM1 in the lung tissue of LPS-induced ALI at
Stella Liong et al.
Placenta, 53, 101-112 (2017-05-11)
Obesity is a growing epidemic, and as a consequence the number of obese pregnancies has also increased. Pregnancy is characterised by maternal and placental inflammation which is intensified with maternal obesity. The proviral integration site for Moloney murine leukemic virus
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