SML0324
JW67
≥98% (HPLC)
别名:
Trispiro[3H-indole-3,2′-[1,3]dioxane-5′,5′′-[1,3]dioxane-2′′,3′′′-[3H]indole]-2,2′′′(1H,1′′′H)-dione (9CI)
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关于此项目
经验公式（希尔记法）:
C21H18N2O6
化学文摘社编号:
分子量:
394.38
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: >5 mg/mL
储存温度
2-8°C
SMILES字符串
O=C1Nc2ccccc2C13OCC4(CO3)COC5(OC4)C(=O)Nc6ccccc56
InChI
1S/C21H18N2O6/c24-17-20(13-5-1-3-7-15(13)22-17)26-9-19(10-27-20)11-28-21(29-12-19)14-6-2-4-8-16(14)23-18(21)25/h1-8H,9-12H2,(H,22,24)(H,23,25)
InChI key
BTXRSHKJNDFHGA-UHFFFAOYSA-N
生化/生理作用
JW67 is an efficient and specific inhibitor of the canonical Wnt signaling in vitro and in vivo.
JW67 is an efficient and specific inhibitor of the canonical Wnt signaling in vitro and in vivo. It appears that JW67 affects the multiprotein complex consisting of β-catenin/GSK-3b/AXIN/APC/CK1 that controls the degradation of β-catenin. JW67 reduces growth of SW480 CRC cells in vitro by inhibiting cell-cycle progression at the G1/S phase.
警示用语：
Danger
危险声明
预防措施声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
Azadeh Yeganeh et al.
Biochimica et biophysica acta, 1861(4), 363-370 (2016-01-19)
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Upasana Sahu et al.
Cell death & disease, 8(3), e2667-e2667 (2017-03-17)
Commensal Escherichia coli has been identified as a major protagonist of microbe-induced colorectal oncogenesis. Its tumour-promoting attribute is linked to the expression of DNA-damaging genotoxins. Using a constitutively invasive variant of non-pathogenic E. coli, we demonstrate that chronic presence of
Zachary P McKay et al.
Journal of immunology (Baltimore, Md. : 1950), 206(6), 1385-1394 (2021-01-29)
Crosstalk between costimulatory and coinhibitory ligands are a prominent node of immune cell regulation. Mounting evidence points toward a critical role for CD155, the poliovirus receptor, in suppressing T cell function, particularly in cancer. However, relative to other known costimulatory/coinhibitory
Rei Nakano et al.
PloS one, 15(3), e0229892-e0229892 (2020-04-02)
The specification of cell identity depends on the exposure of cells to sequences of bioactive ligands. All-trans retinoic acid (ATRA) affects neuronal development in the early stage, and it is involved in neuronal lineage reprogramming. We previously established a fibroblast-like
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