SML0373
CZC-25146 hydrochloride
≥98% (HPLC)
别名:
N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-methanesulfonamide hydrochloride
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关于此项目
经验公式（希尔记法）:
C22H25FN6O4S · HCl
化学文摘社编号:
分子量:
525.00
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: >15 mg/mL (warmed)
储存温度
2-8°C
SMILES字符串
Cl.COc1cc(ccc1Nc2ncc(F)c(Nc3ccccc3NS(C)(=O)=O)n2)N4CCOCC4
InChI
1S/C22H25FN6O4S.ClH/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31;/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27);1H
InChI key
SKYQTYQDKAOHLP-UHFFFAOYSA-N
生化/生理作用
CZC-25146 is a potent selective LRRK2 inhibitor.
CZC-25146 is a potent selective and metabolically stable inhibitor of leucine-rich repeat kinase-2 (LRRK2) also known as dardarin or PARK8, a kinase with mutations linked to Parkinson′s disease. Because the most common mutation, G2019S, enhances LRRK2 kinase activity, it is hoped that LRRK2 inhibitors may be useful in treating the disease. CZC-25146 was shown to prevent mutant LRRK2-induced injury of cultured rodent and human neurons with mid-nanomolar potency.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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