SML0377
(S)-FTY720 phosphate
≥94% (HPLC)
别名:
(+)-(S)-FTY 720 phosphate, (2S)-2-Amino-2-[2-(4-octylphenyl)ethyl]-1-(dihydrogen phosphate)-1,3-propanediol), (S)-FTY 720P
方案
≥94% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
DMSO: 0.3 mg/mL, clear (warmed)
储存温度
−20°C
生化/生理作用
FTY20 phosphate (FTY720-P) is a sphingosine 1-phosphate (S1P) receptor agonist and immunomodulatory agent, the active metabolite of FTY720.
FTY20 phosphate (FTY720-P) is a sphingosine 1-phosphate (S1PR) receptor agonist and immunomodulatory agent, the active metabolite of FTY720. FTY720P acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5), with IC50 values of 0.2-6 nM.
特点和优势
This compound is featured on the Lysophospholipid Receptors and Lysophospholipid Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Nitai C Hait et al.
Nature neuroscience, 17(7), 971-980 (2014-05-27)
FTY720 (fingolimod), an FDA-approved drug for treatment of multiple sclerosis, has beneficial effects in the CNS that are not yet well understood, independent of its effects on immune cell trafficking. We show that FTY720 enters the nucleus, where it is
商品
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