SML0377
(S)-FTY720 phosphate
≥94% (HPLC)
别名:
(+)-(S)-FTY 720 phosphate, (2S)-2-Amino-2-[2-(4-octylphenyl)ethyl]-1-(dihydrogen phosphate)-1,3-propanediol), (S)-FTY 720P
产品名称
(S)-FTY720 phosphate, ≥94% (HPLC)
assay
≥94% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 0.3 mg/mL, clear (warmed)
storage temp.
−20°C
Biochem/physiol Actions
FTY20 phosphate (FTY720-P) is a sphingosine 1-phosphate (S1P) receptor agonist and immunomodulatory agent, the active metabolite of FTY720.
FTY20 phosphate (FTY720-P) is a sphingosine 1-phosphate (S1PR) receptor agonist and immunomodulatory agent, the active metabolite of FTY720. FTY720P acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5), with IC50 values of 0.2-6 nM.
Features and Benefits
This compound is featured on the Lysophospholipid Receptors and Lysophospholipid Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Nitai C Hait et al.
Nature neuroscience, 17(7), 971-980 (2014-05-27)
FTY720 (fingolimod), an FDA-approved drug for treatment of multiple sclerosis, has beneficial effects in the CNS that are not yet well understood, independent of its effects on immune cell trafficking. We show that FTY720 enters the nucleus, where it is
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