SML0410
PT-S58
≥98% (HPLC)
别名:
2-Thiophenecarboxylic acid, 3-[[[4-[(1,1-dimethylethyl)amino]-2-methoxyphenyl]amino]sulfonyl]-, methyl ester
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关于此项目
经验公式（希尔记法）:
C17H22N2O5S2
化学文摘社编号:
分子量:
398.50
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C17H22N2O5S2/c1-17(2,3)18-11-6-7-12(13(10-11)23-4)19-26(21,22)14-8-9-25-15(14)16(20)24-5/h6-10,18-19H,1-5H3
SMILES string
COC1=CC(NC(C)(C)C)=CC=C1NS(C2=C(C(OC)=O)SC=C2)(=O)=O
InChI key
JSUWAIOZKBYWCJ-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL (warmed; clear solution)
storage temp.
2-8°C
Biochem/physiol Actions
PT-S58 is a PPAR β/δ antagonist.
PT-S58 is a PPAR β/δ full antagonist, and a derivative of GSK0660. PT-S58 has a three-fold higher affinity for the receptor than GSK0660 and is a potent inhibitor of agonist-induced target gene expression. Unlike GSK0660, PT-S58 blocks the recruitment co-repressor molecules such as SMRT.
Features and Benefits
This compound is featured on the Nuclear Receptors (Non-Steroids) and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Jayant Lohakare et al.
The Journal of dairy research, 85(3), 295-302 (2018-06-27)
The hypothesis of the study was that inhibition of PPARβ/δ increases glucose uptake and lactose synthesis in bovine mammary epithelial cells by reducing the expression of the glucose transporter mRNA destabiliser calreticulin. Three experiments were conducted to test the hypothesis
Lara Costantini et al.
Journal of clinical medicine, 9(8) (2020-08-07)
The treatment of solid cancers with pharmacological all-trans retinoic acid (ATRA) concentrations, even if it is a gold standard therapy for the acute promyelocytic leukaemia (APL), is not always effective due to some resistance mechanisms. Here the resistance to ATRA
Jie Yu et al.
The Journal of clinical endocrinology and metabolism, 105(9) (2020-07-01)
Implantation is a reproductive bottleneck in women, regulated by fluctuations in ovarian steroid hormone concentrations. However, other nuclear receptor ligands are modifiers of endometrial differentiation leading to successful pregnancy. In the present study we analyzed the effects of peroxisome-proliferator-activated receptor
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Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription factors related to hormone receptors, influencing gene expression.
We offer many products related to non-steroid nuclear receptors for your research needs.
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