SML0431
PQ1 succinate
≥98% (HPLC)
别名:
N1-[6-Methoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]-8-quinolinyl]-1,3-propanediamine butanedioic acid salt, PQ1 succinic acid salt
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C25H28F3N3O6
化学文摘社编号:
分子量:
523.50
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
InChI
1S/C21H22F3N3O2.C4H6O4/c1-13-7-10-27-19-16(26-9-4-8-25)12-17(28-2)20(18(13)19)29-15-6-3-5-14(11-15)21(22,23)24;5-3(6)1-2-4(7)8/h3,5-7,10-12,26H,4,8-9,25H2,1-2H3;1-2H2,(H,5,6)(H,7,8)
SMILES string
OC(=O)CCC(O)=O.COc1cc(NCCCN)c2nccc(C)c2c1Oc3cccc(c3)C(F)(F)F
InChI key
XFEIMRMBZQODRY-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to brown
solubility
DMSO: 15 mg/mL (clear solution)
storage temp.
2-8°C
Biochem/physiol Actions
PQ1 binds tightly to connexin 43 and activates intracellular gap junctions. Treatment of the breast cancer cell line T47D with 200 nM PQ1 induces a 30% increase in gap junctional intercellularcommunication (GJIC) and a 90% decrease in cell growth, with no effect on normal breast epithelial cells.
PQ1 is a Gap Junction ctivator; connexin 43 binder.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Ying Ding et al.
Journal of cancer science & therapy, 4(11), 371-378 (2012-11-01)
Cisplatin is one of the most widely used anti-cancer drugs due to its ability to damage DNA and induce apoptosis. However, increasing reports of side effects and drug resistance indicate the limitation of cisplatin in cancer therapeutics. Recent studies showed
Ying Ding et al.
Apoptosis : an international journal on programmed cell death, 18(9), 1071-1082 (2013-05-17)
Apoptosis, a programmed cell death, is an important control mechanism of cell homeostasis. Deficiency in apoptosis is one of the key features of cancer cells, allowing cells to escape from death. Activation of apoptotic signaling pathway has been a target
Ying Ding et al.
Anti-cancer drugs, 23(9), 897-905 (2012-05-10)
Gap junctions are intercellular channels connecting adjacent cells, allowing cells to transport small molecules. The loss of gap junctional intercellular communication (GJIC) is one of the important hallmarks of cancer. Restoration of GJIC is related to the reduction of tumorigenesis
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持