SML0434
Gue1654
≥98% (HPLC)
别名:
7-(Methylthio)-2-[(2,2-diphenylacetyl)amino]benzo[1,2-d:4,3-d′]bisthiazole
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关于此项目
经验公式（希尔记法）:
C23H17N3OS3
化学文摘社编号:
分子量:
447.60
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL (clear solution; warmed)
storage temp.
2-8°C
SMILES string
CSc1nc2ccc3nc(NC(=O)C(c4ccccc4)c5ccccc5)sc3c2s1
InChI
1S/C23H17N3OS3/c1-28-23-25-17-13-12-16-19(20(17)30-23)29-22(24-16)26-21(27)18(14-8-4-2-5-9-14)15-10-6-3-7-11-15/h2-13,18H,1H3,(H,24,26,27)
InChI key
UFOBDFMYJABXGK-UHFFFAOYSA-N
Biochem/physiol Actions
Gue1654 inhibits signaling of the chemoattractant GPCR 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-oxo-ETE) receptor (OXE-R), but only signaling involving Gβγ, not Gα signaling triggered upon activation of the Gαi-βγ heterotrimer by OXE-R. Gue1654 is the first small-molecule inhibitor for the oxoeicosanoid receptor and the first to uncouple Gα and Gβγ signaling within a heterotrimer for any GPCR.
Gue1654 is an inhibitor of 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-oxo-ETE) receptor (OXE-R) signaling involving Gβγ, not Gα.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML0434-25MG | 04061832786575 |
| SML0434-5MG | 04061832786582 |