SML0454
SM-7368
≥98% (HPLC)
别名:
3-Chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide, SM 7368
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关于此项目
经验公式（希尔记法）:
C10H5ClN4O5S
化学文摘社编号:
分子量:
328.69
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C10H5ClN4O5S/c11-6-3-5(1-2-7(6)14(17)18)9(16)13-10-12-4-8(21-10)15(19)20/h1-4H,(H,12,13,16)
SMILES string
[O-][N+](=O)c1cnc(NC(=O)c2ccc(c(Cl)c2)[N+]([O-])=O)s1
InChI key
XCHLNGBTHLJLFG-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL (clear solution)
storage temp.
2-8°C
Biochem/physiol Actions
SM-7368 is a cell-permeable NF-kB inhibitor.
SM-7368 is a cell-permeable inhibitor of TNF-α-induced MMP-9 upregulation. Also, SM-7368 strongly inhibits TNF-α-induced NF-kB activity but not AP-1 activity. The compound inhibits the TNF-α-induced invasion of HT1080 human fibrosarcoma cell line.
存储类别
11 - Combustible Solids
wgk
WGK 3
法规信息
新产品
此项目有
Dorthe Aasland et al.
Cancer research, 79(1), 99-113 (2018-10-27)
The DNA-methylating drug temozolomide, which induces cell death through apoptosis, is used for the treatment of malignant glioma. Here, we investigate the mechanisms underlying the ability of temozolomide to induce senescence in glioblastoma cells. Temozolomide-induced senescence was triggered by the
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