SML0455
1,2,3,4,5,6-Hexabromocyclohexane
≥98% (HPLC)
别名:
1,2,3,4,5,6-Hexabromocyclohexane, Benzene hexabromide, NSC 7908
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关于此项目
经验公式（希尔记法）:
C6H6Br6
化学文摘社编号:
分子量:
557.54
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL (clear solution, warmed)
storage temp.
room temp
SMILES string
BrC1C(Br)C(Br)C(Br)C(Br)C1Br
InChI
1S/C6H6Br6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H
InChI key
QFQZKISCBJKVHI-UHFFFAOYSA-N
Biochem/physiol Actions
1,2,3,4,5,6-hexabromocyclohexane binds directly to a pocket within the kinase domain of JAK2 and inhibits autophosphorylation. The compound also blocks growth hormone induced JAK2 autophosphorylation without affecting EFGR autophosphorylation.
1,2,3,4,5,6-hexabromocyclohexane is a JAK2 inhibitor.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Jeffrey D Kittilson et al.
Frontiers in endocrinology, 2, 30-30 (2011-01-01)
Previously, we found that the teleost fish, rainbow trout, possesses two growth hormone receptor (GHR) subtypes that display distinct ligand-binding and agonist-induced regulation features. In this study, we used Chinese hamster ovary-K1 cells stably transfected individually with the two trout
Kotaro Horiguchi et al.
Cell and tissue research, 364(2), 395-404 (2015-11-18)
Secretion of hormones by the anterior pituitary gland can be stimulated or inhibited by paracrine factors that are produced during inflammatory reactions. The inflammation cytokine interferon-gamma (IFN-γ) is known to inhibit corticotropin-releasing factor (CRF)-stimulated adrenocorticotropin (ACTH) release but its signaling
Anshu Agrawal et al.
Aging, 4(9), 648-659 (2012-10-16)
Advancing age leads to significant decline in immune functions. IL-21 is produced primarily by T follicular helper (Tfh) cells and is required for effective immune cell functions. Here we compared the induction of IL-21 in aged and young subjects. Our
Xue Jiang et al.
Frontiers in endocrinology, 11, 20-20 (2020-02-23)
In mammals, local production of tumor necrosis factor α (TNFα) inhibits growth hormone (GH)-induced IGF-I expression at tissue level and contributes to GH resistance caused by sepsis/endotoxemia and inflammation. Although the loss of GH responsiveness can be mediated by a
Shirley C Mills et al.
Cellular signalling, 28(4), 316-324 (2016-01-26)
Chemotaxis or directed cell migration is mediated by signalling events initiated by binding of chemokines to their cognate receptors and the activation of a complex signalling cascade. The molecular signalling pathways involved in cell migration are important to understand cancer
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML0455-50MG | 04061833222904 |
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