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Merck
CN

SML0489

BI-87G3

≥98% (HPLC)

别名:

2-(5-Nitrothiazol-2-ylthio)benzo[d]thiazole, 2-[(5-Nitro-2-thiazolyl)thio]-benzothiazole

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关于此项目

经验公式(希尔记法):
C10H5N3O2S3
化学文摘社编号:
分子量:
295.36
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
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InChI

1S/C10H5N3O2S3/c14-13(15)8-5-11-9(17-8)18-10-12-6-3-1-2-4-7(6)16-10/h1-5H

SMILES string

[O-][N+](=O)c1cnc(Sc2nc3ccccc3s2)s1

InChI key

UHBFMJAKLZGVDS-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL (clear solution)

storage temp.

2-8°C

Biochem/physiol Actions

BI-87G3 is a cell-permeable, potent and selective competitive inhibitor of the c-Jun N-terminal kinase (JNK). BI-87G3 is a JNK inhibitor that targets the JIP-JNK interaction site.
BI-87G3 is a selective and potent c-Jun N-terminal kinase (JNK) inhibitor.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Molecular and cellular biology, 39(4) (2018-12-12)
Sphingomyelin phosphodiesterase 3 (SMPD3), a lipid-metabolizing enzyme present in bone and cartilage, has important roles in the developing skeleton. We previously showed that SMPD3 deficiency results in delayed extracellular matrix (ECM) mineralization and severe skeletal deformities in an inducible knockout
Corina A Schmid et al.
The Journal of experimental medicine, 212(5), 775-792 (2015-04-08)
The epigenetic dysregulation of tumor suppressor genes is an important driver of human carcinogenesis. We have combined genome-wide DNA methylation analyses and gene expression profiling after pharmacological DNA demethylation with functional screening to identify novel tumor suppressors in diffuse large

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