SML0498
PNU112455A
≥98% (HPLC)
别名:
4-[(6-amino-4-pyrimidinyl)amino]-benzenesulfonamide hydrochloride
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关于此项目
经验公式（希尔记法）:
C10H11N5O2S · HCl
化学文摘社编号:
分子量:
301.75
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 5 mg/mL (clear solution)
储存温度
2-8°C
SMILES字符串
Cl.Nc1cc(Nc2ccc(cc2)S(N)(=O)=O)ncn1
InChI
1S/C10H11N5O2S.ClH/c11-9-5-10(14-6-13-9)15-7-1-3-8(4-2-7)18(12,16)17;/h1-6H,(H2,12,16,17)(H3,11,13,14,15);1H
InChI key
XBXQRCJKDCEQBS-UHFFFAOYSA-N
生化/生理作用
PNU112455A is a CDK 2/5 inhibitor.
PNU112455A is an ATP site competetive inhibitor of CDK2 and CDK5. The Km for binding to the ATP site of CDK2 and CDK5 is 3.6 and 3.3 mM, respectively.
特点和优势
This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Sholeem Griffin et al.
Biology of reproduction, 99(4), 749-760 (2018-04-25)
Preventing postpartum uterine disease depends on the ability of endometrial cells to tolerate the presence of the bacteria that invade the uterus after parturition. Postpartum uterine disease and endometrial pathology in cattle are most associated with the pathogen Trueperella pyogenes.
商品
Review properties, activators and inhibitors, and available products for researching cyclin-dependent kinases (CDKs).
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