SML0498
PNU112455A
≥98% (HPLC)
别名:
4-[(6-amino-4-pyrimidinyl)amino]-benzenesulfonamide hydrochloride
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关于此项目
经验公式（希尔记法）:
C10H11N5O2S · HCl
化学文摘社编号:
分子量:
301.75
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C10H11N5O2S.ClH/c11-9-5-10(14-6-13-9)15-7-1-3-8(4-2-7)18(12,16)17;/h1-6H,(H2,12,16,17)(H3,11,13,14,15);1H
SMILES string
Cl.Nc1cc(Nc2ccc(cc2)S(N)(=O)=O)ncn1
InChI key
XBXQRCJKDCEQBS-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL (clear solution)
storage temp.
2-8°C
Biochem/physiol Actions
PNU112455A is a CDK 2/5 inhibitor.
PNU112455A is an ATP site competetive inhibitor of CDK2 and CDK5. The Km for binding to the ATP site of CDK2 and CDK5 is 3.6 and 3.3 mM, respectively.
Features and Benefits
This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Sholeem Griffin et al.
Biology of reproduction, 99(4), 749-760 (2018-04-25)
Preventing postpartum uterine disease depends on the ability of endometrial cells to tolerate the presence of the bacteria that invade the uterus after parturition. Postpartum uterine disease and endometrial pathology in cattle are most associated with the pathogen Trueperella pyogenes.
商品
Review properties, activators and inhibitors, and available products for researching cyclin-dependent kinases (CDKs).
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