SML0523
ISPA-28
≥98% (HPLC)
别名:
N-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-4,5-dihydro-5-Isoxazolecarboxamide
产品名称
ISPA-28, ≥98% (HPLC)
InChI key
YMLINDVVJXDIRW-UHFFFAOYSA-N
InChI
1S/C21H24N6O3/c1-5-26-12-16(13(2)23-26)17-11-18(30-24-17)20(28)22-19-14(3)25(4)27(21(19)29)15-9-7-6-8-10-15/h6-10,12,18H,5,11H2,1-4H3,(H,22,28)
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
Biochem/physiol Actions
ISPA-28 is an inhibitor of the plasmodial surface anion channel (PSAC).
ISPA-28 is an inhibitor of the plasmodial surface anion channel (PSAC). ISPA-28 is 800 fold more potent against PSAC expressed by the P. falciparum strain Dd2 over PSAC expressed by the HB23 strain. PSAC is incorporated into the membranes of Plasmodium-infected red blood cells, resulting in increased permeability to nutrients required for pathogen growth.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Paresh Sharma et al.
The Journal of biological chemistry, 288(27), 19429-19440 (2013-05-31)
Acquired antimalarial drug resistance produces treatment failures and has led to periods of global disease resurgence. In Plasmodium falciparum, resistance is known to arise through genome-level changes such as mutations and gene duplications. We now report an epigenetic resistance mechanism
David A Hill et al.
Future microbiology, 5(1), 81-97 (2009-12-22)
Erythrocytes infected with plasmodia, including those that cause human malaria, have increased permeability to a diverse collection of organic and inorganic solutes. While these increases have been known for decades, their mechanistic basis was unclear until electrophysiological studies revealed flux
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