SML0540
羟基保泰松
≥98% (HPLC), non-steroid anti inflammatory drug, powder
别名:
p-Oxyphenylbutazone, 4-Butyl-1-(4-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione, G 27202, NSC 526053, Ro 04-4410, p-Hydroxyphenylbutazone
产品名称
羟基保泰松, ≥98% (HPLC)
SMILES string
N2(N(C(=O)C(C2=O)CCCC)c3ccccc3)c1ccc(cc1)O
InChI
1S/C19H20N2O3/c1-2-3-9-17-18(23)20(14-7-5-4-6-8-14)21(19(17)24)15-10-12-16(22)13-11-15/h4-8,10-13,17,22H,2-3,9H2,1H3
InChI key
HFHZKZSRXITVMK-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to brown
solubility
DMSO: 10 mg/mL, clear
storage temp.
−20°C
Quality Level
相关类别
General description
Oxyphenbutazone is a derivative compound of phenylbutazone.
Biochem/physiol Actions
Oxyphenbutazone is a non-steroid anti inflammatory; anti Mycobacterium tuberculosis agent.
Oxyphenbutazone is a non-steroid anti inflammatory; anti Mycobacterium tuberculosis agent. Oxyphenbutazone is known to cause inflammatory effects on tissues. Oxyphenbutazone, as a drug, decreases cellular exudates, without involving the pituitary-adrenal axis or the immunity response. Though the drug delivers a number of side effects, it is considered to be less toxic than phenylbutazone, due to decreased rate of intestinal absorption.
Oxyphenbutazone is an NSAID that has been shown to preferentially kill non-replicating Mycobaterium tuberculosis maintained in media that simulates the mildly acidic, in vivo conditions where drug-resistant, non replicating subpopulations of the bacteria reside in hosts. The compound has little or no affect on replication M. tuberculosis grown in normal liquid cultures.
Other Notes
Air sensitive
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Ulcer of the cecum during oxyphenbutazone (tandearil) therapy.
Debenham G P
Canadian Medical Association Journal, 94(22), 1182-1182 (1966)
M D Veiga et al.
Journal of pharmaceutical and biomedical analysis, 28(5), 973-982 (2002-06-01)
The interactions between a nonsteroidal anti-inflammatory drugs, oxyphenbutazone (OPB), with two cyclodextrins, beta-cyclodextrin (beta-CD) and gamma-cyclodextrin (gamma-CD), have been studied in an aqueous medium and in the solid state. Differential scanning calorimetry, hot stage microscopy, thermogravimetric analysis and X-ray diffraction
I A Wasfi et al.
American journal of veterinary research, 58(6), 636-640 (1997-06-01)
To document disposition variables of phenylbutazone and its metabolite, oxyphenbutazone, in camels (Camelus dromedarius) after single i.v. bolus administration of phenylbutazone, with a view to making recommendation on avoiding violative residues in racing camels. 6 healthy camels (4 males, 2
B Razdan et al.
Drug development and industrial pharmacy, 25(9), 1051-1056 (1999-10-13)
Dissolution-dialysis studies of commercial tablets of oxyphenbutazone were carried out to establish the applicability of this technique for the in vitro evaluation of oxyphenbutazone dosage form. While disintegration time and dissolution rate studies did not give a true indication of
A Kadir et al.
Journal of veterinary pharmacology and therapeutics, 20(1), 54-60 (1997-02-01)
Phenylbutazone was administered intravenously and intramuscularly at a dosage rate of 4.4 mg/kg to a group of 6 female camels in a two-period crossover study. After intravenous (i.v.) administration, disposition was characterised by a two-compartment open model, with a low
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