SML0566
VU0359595
≥97% (HPLC)
别名:
(1R,2R)-N-([S]-1-{4-[5-Bromo-2-oxo-2,3-dihydro-1H-benzo(d)imidazol-1-yl]piperidin-1-yl}propan-2-yl)-2-phenylcyclopropanecarboxamide
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关于此项目
经验公式（希尔记法）:
C25H29BrN4O2
化学文摘社编号:
分子量:
497.43
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41106300
MDL number:
InChI key
JSVNNLRZCJAYTQ-ORYQWCPZSA-N
SMILES string
O=C1N(C2CCN(C[C@H](C)NC([C@H]3[C@H](C4=CC=CC=C4)C3)=O)CC2)C5=CC=C(Br)C=C5N1
InChI
1S/C25H29BrN4O2/c1-16(27-24(31)21-14-20(21)17-5-3-2-4-6-17)15-29-11-9-19(10-12-29)30-23-8-7-18(26)13-22(23)28-25(30)32/h2-8,13,16,19-21H,9-12,14-15H2,1H3,(H,27,31)(H,28,32)/t16-,20-,21+/m0/s1
assay
≥97% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
VU0359595 is a PLD1 specific inhibitor with an IC50 of 3.7 nM, and 1500-fold selectivity over PLD2 (IC50 = 6.4 μM).
VU0359595 is a PLD1 specific inhibitor.
Features and Benefits
This compound is featured on the Phospholipase D page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Xuelin Han et al.
PloS one, 6(7), e21468-e21468 (2011-07-16)
The internalization of Aspergillus fumigatus into lung epithelial cells is a process that depends on host cell actin dynamics. The host membrane phosphatidylcholine cleavage driven by phospholipase D (PLD) is closely related to cellular actin dynamics. However, little is known
商品
PLD enzymes catalyze PC hydrolysis, influencing substrate recognition and lipid metabolism.
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