SML0570
21H7
≥98% (HPLC)
别名:
6-Bromo-2-methyl-4-quinolinecarboxylic acid 2-[(2-hydroxyphenyl)methylene]hydrazide;
登录查看公司和协议定价
选择尺寸
关于此项目
经验公式（希尔记法）:
C18H14BrN3O2
化学文摘社编号:
分子量:
384.23
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 5 mg/mL, clear (warmed)
储存温度
2-8°C
SMILES字符串
Cc1cc(C(=O)NN=Cc2ccccc2O)c3cc(Br)ccc3n1
InChI
1S/C18H14BrN3O2/c1-11-8-15(14-9-13(19)6-7-16(14)21-11)18(24)22-20-10-12-4-2-3-5-17(12)23/h2-10,23H,1H3,(H,22,24)
InChI key
MTVVJOBPGQXHML-UHFFFAOYSA-N
生化/生理作用
21H7 is an inhibitor of Wnt/β-catenin signaling that act downstream of the symb-catenin destruction complex to inhibit both Wnt-induced and cancer associated constitutive Wnt signaling via destabilization of β-catenin. The compound chelates iron in vitro and in intact cells. 21H7 decrease the viability of mouse B-lymphoma W10 cells, with LD50 values of 0.4 to 1.0 μM, while is significantly less cytotoxic to normal cells.
21H7 is an inhibitor of Wnt/β-catenin signaling that act downstream of the symb-catenin destruction complex.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Sheqing Ji et al.
Oncology research, 25(9), 1633-1641 (2017-03-03)
Increased expression of YEATS domain containing 4 (YEATS4) has been reported to have a correlation with progression in many types of cancer. However, the mechanism by which it promotes the development of gastric cancer (GC) is rarely reported. This study
Xianyan Chen et al.
Frontiers in pharmacology, 10, 1528-1528 (2020-02-11)
Dihydrotestosterone (DHT) is the most potent androgen that regulates hair cycling. Hair cycling involves cross-talk between the androgen and Wnt/β-catenin pathways. However, how DHT regulates hair follicle (HF) growth through the Wnt/β-catenin pathway has not been well investigated. This study
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持