SML0641
BAM7
≥98% (HPLC)
别名:
4-(2-(2-Ethoxyphenyl)hydrazono)-3-methyl-1-(4-phenylthiazol-2-yl)-1H-pyrazol-5(4H)-one, BAX activator molecule 7
方案
≥98% (HPLC)
表单
powder
颜色
light orange to dark orange
溶解性
DMSO: 2 mg/mL, clear (warmed)
储存温度
2-8°C
生化/生理作用
BAM7 is a selective activator of BAX, a proapoptotic member of the BCL-2 protein family. BAM7 binds directly to the BAX trigger site, a distinct BH3 binding site that regulates BAX activation, inducing BAX oligomerization, which enables the release of apoptogenic factors that result in cell death. BAM7 is selective for this previously unknown BH3-binding groove on the N-terminal face of BAX.
BAM7 is a selective proapoptotic BAX activator.
历史批次信息供参考:
Tim Sen Wang et al.
Developmental cell, 53(6), 627-645 (2020-06-07)
Mitochondrial outer membrane permeabilization (MOMP) is a core event in apoptosis signaling. However, the underlying mechanism of BAX and BAK pore formation remains incompletely understood. We demonstrate that mitochondria are globally and dynamically targeted by endolysosomes (ELs) during MOMP. In
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