SML0677
IWP12
≥98% (HPLC)
别名:
IWP-12, N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3,6-dimethyl-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
InChI
1S/C18H18N4O2S3/c1-9-4-5-11-13(6-9)27-17(19-11)21-14(23)8-25-18-20-12-7-10(2)26-15(12)16(24)22(18)3/h4-6,10H,7-8H2,1-3H3,(H,19,21,23)
InChI key
RBFDSBJDWZOTGR-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
IWP (inhibitor of Wnt production) inhibitors are known to prevent Wnt protein generation. Abnormal Wnt signalling associated with tumorigenesis and metastasis of tumors.
IWP12 is Wnt inhibitor that prevents palmitylation of Wnt proteins by Porcupine (Porcn), which is suitable for in vivo assays. IWP12 blocked post resection juvenile zebrafish tailfin regeneration.
IWP12 is Wnt inhibitor.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
The development of highly potent inhibitors for porcupine.
Wang X, et al.
Journal of Medicinal Chemistry, 56(6), 2700-2704 (2013)
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