SML0677
IWP12
≥98% (HPLC)
别名:
IWP-12, N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3,6-dimethyl-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 5 mg/mL, clear
储存温度
2-8°C
InChI
1S/C18H18N4O2S3/c1-9-4-5-11-13(6-9)27-17(19-11)21-14(23)8-25-18-20-12-7-10(2)26-15(12)16(24)22(18)3/h4-6,10H,7-8H2,1-3H3,(H,19,21,23)
InChI key
RBFDSBJDWZOTGR-UHFFFAOYSA-N
生化/生理作用
IWP (inhibitor of Wnt production) inhibitors are known to prevent Wnt protein generation. Abnormal Wnt signalling associated with tumorigenesis and metastasis of tumors.
IWP12 is Wnt inhibitor that prevents palmitylation of Wnt proteins by Porcupine (Porcn), which is suitable for in vivo assays. IWP12 blocked post resection juvenile zebrafish tailfin regeneration.
IWP12 is Wnt inhibitor.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
The development of highly potent inhibitors for porcupine.
Wang X, et al.
Journal of Medicinal Chemistry, 56(6), 2700-2704 (2013)
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