SML0708
BMS-182874 hydrochloride
≥98% (HPLC)
别名:
5-(Dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide hydrochloride, BMS182874, N-(3,4-Dimethyl-5-isoxazolyl)-5-(dimethylamino)-1-naphthalenesulfonamide hydrochloride
产品名称
BMS-182874 hydrochloride, ≥98% (HPLC)
InChI
1S/C17H19N3O3S.ClH/c1-11-12(2)18-23-17(11)19-24(21,22)16-10-6-7-13-14(16)8-5-9-15(13)20(3)4;/h5-10,19H,1-4H3;1H
InChI key
UZZFRNZGYDOBAO-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
Biochem/physiol Actions
BMS-182874 is a potent selective nonpeptide endothelin ETA receptor antagonist.
BMS-182874 is a potent selective nonpeptide endothelin ETA receptor antagonist. BMS-182874 is 1000-fold selective for ETA over ETA B receptors with a Ki of 48 nM for ETA receptors vs >50 μM for ETB.
Features and Benefits
This compound is featured on the Endothelin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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