SML0722
CU-CPT22
≥98% (HPLC)
别名:
5H-Benzocycloheptene-8-carboxylic acid, 3,4,6-trihydroxy-2-methoxy-5-oxo-, hexyl ester
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关于此项目
经验公式（希尔记法）:
C19H22O7
化学文摘社编号:
分子量:
362.37
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C19H22O7/c1-3-4-5-6-7-26-19(24)12-8-11-10-14(25-2)17(22)18(23)15(11)16(21)13(20)9-12/h8-10,22-23H,3-7H2,1-2H3,(H,20,21)
SMILES string
OC1=C(O)C(OC)=CC2=C1C(C(O)=CC(C(OCCCCCC)=O)=C2)=O
InChI key
UBQFTTUFRSSOHE-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
orange to dark red
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
CU-CPT22 is the first probe for the complex between toll-like receptors TLR1 and TLR2.
CU-CPT22 is the first probe for the complex between toll-like receptors TLR1 and TLR2. CU-CPT22 binds at the interface of TLR1 and TLR2.
signalword
Danger
hcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Resp. Sens. 1
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Qi Su et al.
International journal of medical microbiology : IJMM, 307(2), 108-112 (2016-12-28)
Propionibacterium acnes has been considered as a crucial contributor to the pathogenesis of acne vulgaris. The interaction between P. acnes and the host is mainly mediated by Toll like receptor (TLR) 2 recognition. TLR2 homodimers recognize P. acnes in mice
Minjee Choi et al.
Scandinavian journal of immunology, 89(6), e12764-e12764 (2019-03-21)
Serum amyloid A (SAA) is an acute phase protein with pro-inflammatory cytokine-like properties. Recent studies have revealed that SAA promoted interleukin-17 (IL-17) production by various cells, including γδ T cells. γδ T cells are innate immune cells and express Toll-like
Jieun Kim et al.
Nutrients, 10(7) (2018-07-07)
Toll-like receptor 2 (TLR2) responses are involved in various inflammatory immune disorders. Phloretin is a naturally occurring dietary flavonoid that is abundant in fruit. Here, we investigated whether the anti-inflammatory activity of phloretin is mediated through TLR2 pathways, and whether
Laura Facci et al.
Journal of neuroinflammation, 15(1), 164-164 (2018-05-29)
Acute-phase response is a systemic reaction to environmental/inflammatory insults and involves production of acute-phase proteins, including serum amyloid A (SAA). Interleukin-1β (IL-1β), a master regulator of neuroinflammation produced by activated inflammatory cells of the myeloid lineage, in particular microglia, plays
Acute myeloid leukaemia-derived Langerhans-like cells enhance Th1 polarization upon TLR2 engagement.
Stephanie Bock et al.
Pharmacological research, 105, 44-53 (2016-01-23)
Langerhans cells (LCs) represent a highly specialized subset of epidermal dendritic cells (DCs), yet not fully understood in their function of balancing skin immunity. Here, we investigated in vitro generated Langerhans-like cells obtained from the human acute myeloid leukaemia cell
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