SML0726
泛环氧酮
from Lentinus conatus, ≥95% (HPLC)
别名:
(1S,5R,6S)-5-Hydroxy-3-[(1S)-1-hydroxy-3-methyl-2-buten-1-yl]-7-oxabicyclo[4.1.0]hept-3-en-2-one
InChI
1S/C11H14O4/c1-5(2)3-7(12)6-4-8(13)10-11(15-10)9(6)14/h3-4,7-8,10-13H,1-2H3/t7?,8-,10+,11-/m1/s1
InChI key
MBXKEYXHJAZKBP-VQZXEUHYSA-N
biological source
Lentinus conatus
assay
≥95% (HPLC)
form
powder
storage condition
protect from light
solubility
DMSO: soluble 10 mg/mL
storage temp.
−20°C
Biochem/physiol Actions
Panepoxydone is a fungal metabolite that inhibits NF-κB transcription factor by preventing IκB phosphorylation, thus inhibiting the release of NF-κB from the IκB : NF-κB complex and its translocation into the nucleus. Panepoxydone also has antimalarial, cytotoxic activities and anti-parasitic activity against Trypanosoma cruzi.
Panepoxydone is a fungal metabolite that inhibits NF-κB transcription factor.
Preparation Note
Soluble in ethyl acetate, ethanol, and DMSO (10mg/ml). The product is soluble, but not stable in water and methanol.
Other Notes
Store the product sealed at -20 °C, protect from light. Under these conditions, the product is stable for at least 2 years.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
E M Souza-Fagundes et al.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 43(11), 1054-1061 (2010-11-23)
Hypnophilin and panepoxydone, terpenoids isolated from Lentinus strigosus, have significant inhibitory activity on Trypanosoma cruzi trypanothione reductase (TR). Although they have similar TR inhibitory activity at 10 μg/mL (40.3 μM and 47.6 μM for hypnophilin and panepoxydone, respectively; ~100%), hypnophilin
J Brad Shotwell et al.
Bioorganic & medicinal chemistry letters, 12(23), 3463-3466 (2002-11-07)
A number of inhibitors of NF-kappaB signaling arising from our recent syntheses of isopanepoxydone and panepoxydone have been identified. Structure-activity data have been correlated to allow the design and synthesis of an affinity reagent for the isolation and identification of
Z Y Jiang et al.
Placenta, 33(1), 1-7 (2011-11-04)
To date, the relationship between inflammatory cytokines and progesterone receptors (PRs) has been little studied, although both mediate the mechanism of parturition in human deciduas. Thus, the aim of study was to investigate the role of an inflammatory cytokine, tumor
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