SML0787
AC 42
≥98% (HPLC)
别名:
4-(4-Butyl-1-piperidinyl)-1-(2-methylphenyl)-1-butanone hydrochloride, AC-42
SMILES string
Cl.N2(CCC(CC2)CCCC)CCCC(=O)c1c(cccc1)C
InChI
1S/C20H31NO.ClH/c1-3-4-9-18-12-15-21(16-13-18)14-7-11-20(22)19-10-6-5-8-17(19)2;/h5-6,8,10,18H,3-4,7,9,11-16H2,1-2H3;1H
InChI key
HJCOVULGUXGGSU-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
AC-42 is a specific agonist of the muscarininc M1 receptor (pEC50 = 6.54) with little or no activity against other muscarinic receptor family members. AC-42 binds to an allosteric site adjacent to the adjacent to the orthosteric, acetylcholine binding site.
AC-42 is a specific agonist of the muscarininc M1 receptor.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Beatrice Mihaela Radu et al.
Scientific reports, 7(1), 5083-5083 (2017-07-13)
Clinical and experimental studies indicate that muscarinic acetylcholine receptors are potential pharmacological targets for the treatment of neurological diseases. Although these receptors have been described in human, bovine and rat cerebral microvascular tissue, a subtype functional characterization in mouse brain
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