SML0821
UCD38B hydrochloride
≥98% (HPLC)
别名:
5’-Benzylglycinyl-amiloride, N-[6-Amino-5-[[(aminoiminomethyl)amino]carbonyl]-3-chloro-2-pyrazinyl]-glycine phenylmethyl ester hydrochloride
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关于此项目
经验公式（希尔记法）:
C15H16ClN7O3 · xHCl
化学文摘社编号:
分子量:
377.79 (free base basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
SMILES string
NC(NC(C(N=C1Cl)=C(N)N=C1CNC(OCC2=CC=CC=C2)=O)=O)=N.[H]Cl
InChI
1S/C15H16ClN7O3.ClH/c16-11-9(21-12(17)10(22-11)13(24)23-14(18)19)6-20-15(25)26-7-8-4-2-1-3-5-8;/h1-5H,6-7H2,(H2,17,21)(H,20,25)(H4,18,19,23,24);1H
InChI key
SFHYWDNJBRFZKW-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 15 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
UCD38B is a cell permeable inhibitor of intracellular uPA (urokinase plasminogen activator) that is cytotoxic to proliferating and non-proliferating glioma cell lines.
UCD38B is a cell permeable inhibitor of intracellular uPA (urokinase plasminogen activator) that is cytotoxic to proliferating and non-proliferating glioma cell lines. UCD38B induces caspase-independent necrosis in U87 glioma MDA231 breast cancer cells. It appears that the necrotic pathway is mediated by AIF (apoptotic inducible factor).
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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