assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 3 mg/mL, clear (warmed)
storage temp.
2-8°C
InChI
1S/C13H15N5O3/c1-2-17-12(20)8-5-7(10(15)19)9(14)16-11(8)18(13(17)21)6-3-4-6/h5-6H,2-4H2,1H3,(H2,14,16)(H2,15,19)
InChI key
HWODCHXORCTEGU-UHFFFAOYSA-N
Application
A-484954已被用作选择性和强效抑制剂来抑制eEF2K（真核伸长因子2激酶），以检查海马CA1区放射状层中突触传递的增强。它也已用作eEF2K 抑制剂来监测U2OS Arntl::dLUC 细胞的实时发光。
Biochem/physiol Actions
A-484954是一种有效、选择性的真核伸长因子2激酶 (eEF2K)抑制剂。
A-484954是一种有效、选择性的真核伸长因子2激酶 (eEF2K)抑制剂。蛋白质合成所需的真核伸长因子-2在被eEF2K磷酸化后被灭活。
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存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Potentiation of Schaffer-Collateral CA1 Synaptic Transmission by eEF2K and p38 MAPK Mediated Mechanisms
Weng W, et al.
Frontiers in Cellular Neuroscience, 10, 247-247 (2016)
Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
Walton Z E, et al.
Cell (2018)
Kanzo Suzuki et al.
Cell reports, 37(5), 109918-109918 (2021-11-04)
Ketamine is a noncompetitive glutamatergic N-methyl-d-aspartate receptor (NMDAR) antagonist that exerts rapid antidepressant effects. Preclinical studies identify eukaryotic elongation factor 2 kinase (eEF2K) signaling as essential for the rapid antidepressant action of ketamine. Here, we combine genetic, electrophysiological, and pharmacological
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML0861-5MG | 04061832451114 |
| SML0861-25MG | 04061832451107 |