SML0920
α-Phenyl tropolone
≥98% (HPLC)
别名:
2-Hydroxy-3-phenyl-2,4,6-cycloheptatrien-1-one, 3-Phenyltropolone
方案
≥98% (HPLC)
表单
powder
颜色
, yellow to gray to brown
溶解性
DMSO: 20 mg/mL, clear
储存温度
2-8°C
生化/生理作用
α-Phenyl tropolone is a very potent inhibitor of the hisotne deacetylases HDAC2 and HDAC8 (Ki = 0.26 and 1.09 nM, respectively). The compound, α-Phenyl tropolone, does not affect other HDAC isoforms up to concentrations of 20 μM, with the exception of HDAC 6 (Ki = 527 nM).
α-Phenyl tropolone is a very potent inhibitor of the hisotne deacetylases HDAC2 and HDAC8.
特点和优势
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Aquatic Chronic 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
S V Demyanenko et al.
Brain research bulletin, 162, 151-165 (2020-06-28)
Epigenetic processes play important roles in brain responses to ischemic injury. We studied effects of photothrombotic stroke (PTS, a model of ischemic stroke) on the intracellular level and cellular localization of histone deacetylases HDAC3, HDAC4 and HDAC6 in the rat
商品
We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.
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