SML0920
α-Phenyl tropolone
≥98% (HPLC)
别名:
2-Hydroxy-3-phenyl-2,4,6-cycloheptatrien-1-one, 3-Phenyltropolone
assay
≥98% (HPLC)
form
powder
color
, yellow to gray to brown
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
α-Phenyl tropolone is a very potent inhibitor of the hisotne deacetylases HDAC2 and HDAC8 (Ki = 0.26 and 1.09 nM, respectively). The compound, α-Phenyl tropolone, does not affect other HDAC isoforms up to concentrations of 20 μM, with the exception of HDAC 6 (Ki = 527 nM).
α-Phenyl tropolone is a very potent inhibitor of the hisotne deacetylases HDAC2 and HDAC8.
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
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Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
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S V Demyanenko et al.
Brain research bulletin, 162, 151-165 (2020-06-28)
Epigenetic processes play important roles in brain responses to ischemic injury. We studied effects of photothrombotic stroke (PTS, a model of ischemic stroke) on the intracellular level and cellular localization of histone deacetylases HDAC3, HDAC4 and HDAC6 in the rat
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