SML0968
Y11
≥98% (HPLC)
别名:
1-(2-Hydroxyethyl)-3,5,7-Triaza-1-azoniatricyclo[3.3.1.13,7]decane bromide, NSC206142
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
H2O: 25 mg/mL, clear
储存温度
−20°C
生化/生理作用
Y11 inhibits the activity of focal adhesion kinase (FAK) by binding to the amino-terminal domain of FAK and blocking autophosphorylation of tyrosine residue Y397. Y11 inhibits the viability of SW620 and BT474 cancer cell lines and significantly reduces tumor volume in mouse xenografts.
Y11 inhibits the activity of focal adhesion kinase (FAK).
Y11 has high cytotoxic effects with IC50 values ranging from 3.87 to 4.66 mM, against non-small cell lung carcinoma (NSCLC) A549 cells. It plays a major role in the protein structures across the kunitz protein domain of viperids and elapids.
特点和优势
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警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Synthesis of novel tetrandrine derivatives and their inhibition against NSCLC A549 cells
Yang, et al.
Journal of Asian natural products research, 1-11 (2018)
Comparative analyses of putative toxin gene homologs from an Old World viper, Daboia russelii
Krishnan, et al.
PeerJ, 5, e4104-e4104 (2017)
商品
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