SML0968
Y11
≥98% (HPLC)
别名:
1-(2-Hydroxyethyl)-3,5,7-Triaza-1-azoniatricyclo[3.3.1.13,7]decane bromide, NSC206142
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 25 mg/mL, clear
storage temp.
−20°C
Biochem/physiol Actions
Y11 inhibits the activity of focal adhesion kinase (FAK) by binding to the amino-terminal domain of FAK and blocking autophosphorylation of tyrosine residue Y397. Y11 inhibits the viability of SW620 and BT474 cancer cell lines and significantly reduces tumor volume in mouse xenografts.
Y11 inhibits the activity of focal adhesion kinase (FAK).
Y11 has high cytotoxic effects with IC50 values ranging from 3.87 to 4.66 mM, against non-small cell lung carcinoma (NSCLC) A549 cells. It plays a major role in the protein structures across the kunitz protein domain of viperids and elapids.
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Synthesis of novel tetrandrine derivatives and their inhibition against NSCLC A549 cells
Yang, et al.
Journal of Asian natural products research, 1-11 (2018)
Comparative analyses of putative toxin gene homologs from an Old World viper, Daboia russelii
Krishnan, et al.
PeerJ, 5, e4104-e4104 (2017)
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