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Merck
CN

SML1113

RSC133

≥98% (HPLC)

别名:

3-[[(2E)-3-(1H-Indol-3-yl)-1-oxo-2-propen-1-yl]amino]-benzamide, RSC 133, Reprogramming stimulating compound 133

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关于此项目

经验公式（希尔记法）:
C18H15N3O2
化学文摘社编号:
1418131-46-0
分子量:
305.33
UNSPSC Code:
12352200
PubChem Substance ID:
329825654
NACRES:
NA.77

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SMILES string

NC(C1=CC=CC(NC(/C=C/C2=CNC3=C2C=CC=C3)=O)=C1)=O

InChI

1S/C18H15N3O2/c19-18(23)12-4-3-5-14(10-12)21-17(22)9-8-13-11-20-16-7-2-1-6-15(13)16/h1-11,20H,(H2,19,23)(H,21,22)/b9-8+

InChI key

HYUDSQGICKAEGE-CMDGGOBGSA-N

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

white to light brown

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

RSC133 is an epigenetic modulator that effectively enhances reprogramming of human somatic cells and maintenance of human stem cell pluripotency.
RSC133 is an epigenetic modulator that effectively enhances reprogramming of human somatic cells and maintenance of human stem cell pluripotency. Apparently, RSC133 facilitates the reprograming by dual inhibition of histone deacetylase and DNA methyltransferase activities. In hFFs, RSC133 rapidly activates pluripotency-associated genes Nanog, Oct4, and Rex1 up to 2- to 2.5-fold. RSC133 exerts positive effects on cell proliferation and ablates pro-senescence phenotypes.

Features and Benefits

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Other Notes

Light sensitive

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
084M4613V

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Jungwoon Lee et al.
Angewandte Chemie (International ed. in English), 51(50), 12509-12513 (2012-11-06)
Booster of pluripotency: RSC133, a new synthetic derivative of indoleacrylic acid/indolepropionic acid, exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. Furthermore it potently improves the reprogramming of human somatic cells into a pluripotent state and aids the growth

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