assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
ML318 is a biaryl nitrile inhibitor of PvdQ acylase. It decreases the intracellular uptake of iron inside the bacteria.
ML318 is an inhibitor of the siderophore PvdQ (pyoverdine Q), a peptide iron scavenger found in bacteria. ML318 inhibits the biosynthesis of one step in the pyoverdine biosynthesis with an IC50 of 20 nM, and is active in cells.
ML318 is an inhibitor of the siderophore PvdQ (pyoverdine Q).
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Identification of a small molecule inhibitor of Pseudomonas aeruginosa PvdQ acylase, an enzyme involved in siderophore pyoverdine synthesis
Probe Reports from the NIH Molecular Libraries Program (2013)
Jacqueline M Wurst et al.
ACS chemical biology, 9(7), 1536-1544 (2014-05-16)
Pseudomonas aeruginosa produces the peptide siderophore pyoverdine, which is used to acquire essential Fe(3+) ions from the environment. PvdQ, an Ntn hydrolase, is required for the biosynthesis of pyoverdine. PvdQ knockout strains are not infectious in model systems, suggesting that
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML1204-5MG | 04061832636474 |
| SML1204-25MG | 04061832636467 |
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