SML1215
Cuspin-1
≥98% (HPLC)
别名:
(5-Bromo-3-pyridinyl)(4-methylphenyl)methanone
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关于此项目
经验公式（希尔记法）:
C13H10BrNO
化学文摘社编号:
分子量:
276.13
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 5 mg/mL, clear (warmed)
储存温度
room temp
SMILES字符串
CC(C=C1)=CC=C1C(C2=CC(Br)=CN=C2)=O
InChI
1S/C13H10BrNO/c1-9-2-4-10(5-3-9)13(16)11-6-12(14)8-15-7-11/h2-8H,1H3
InChI key
AJZRSLVRFSCCIL-UHFFFAOYSA-N
生化/生理作用
Cuspin-1 (Chemical Upregulator of SMN Protein-1) is an upregulator of the Survival of Motor Neuron protein (SMN), necessary for survival of motor neurons. SMN is decreased in the neurodegenerative disease Spinal Muscular Atrophy (SMA), an autosomal recessive disease caused by a genetic defect in the SMN1 gene. SMA is the second leading cause of neuromuscular disease, after Duchenne muscular dystrophy. Cuspin-1 increased SMN levels by 50-100% in SMA patient fibroblast cells accompanied by an increase in the phosphorylation of Erk, suggesting inbvolvement of the Ras-Raf-MEK cascade.
Cuspin-1 (Chemical Upregulator of SMN Protein-1) is an upregulator of the Survival of Motor Neuron protein (SMN).
储存分类代码
11 - Combustible Solids
WGK
WGK 3
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